Background

Alcohol use disorder is a chronic recurrent encephalopathy, and its pathogenesis has not been fully understood. Among possible explanations, neuroinflammation caused by the disorders of brain central immune signaling has been identified as one possible mechanism of alcohol use disorder. As the basic components of cells and important bioactive molecules, sphingolipids are essential in regulating many cellular activities. Recent studies have shown that sphingolipids-mediated neuroinflammation may be involved in the development of alcohol use disorder.

Methods

PubMed databases were searched for literature on sphingolipids and alcohol use disorder (alcohol abuse, alcohol addiction, alcohol dependence, and alcohol misuse) including evidence of the relationship between sphingolipids-mediated neuroinflammation and alcohol use disorder (formation, withdrawal, treatment).

Results

Disorders of sphingolipid metabolism, including the different types of sphingolipids and regulatory enzyme activity, have been found in patients with alcohol use disorder as well as animal models, which in turn cause neuro-inflammation in the central nervous system. Thus, these disorders may also be an important mechanism in the development of alcohol use disorder in patients. In addition, different sphingolipids may have different or even reverse effects on alcohol use disorder.

Conclusions

The sphingolipids-mediated neuroinflammation plays an important role in the development of alcohol use disorder. This review proposes a potential approach to prevent and treat alcohol use disorders by manipulating sphingolipid metabolism.

中文翻译：

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鞘脂介导的神经炎症与酒精使用障碍之间的关系

背景

酒精使用障碍是一种慢性复发性脑病，其发病机制尚未完全清楚。在可能的解释中，大脑中枢免疫信号紊乱引起的神经炎症已被确定为酒精使用障碍的一种可能机制。鞘脂作为细胞的基本成分和重要的生物活性分子，在调节许多细胞活动中发挥着重要作用。最近的研究表明，鞘脂介导的神经炎症可能与酒精使用障碍的发展有关。

方法

在 PubMed 数据库中检索了有关鞘脂和酒精使用障碍（酒精滥用、酒精成瘾、酒精依赖和酒精滥用）的文献，包括鞘脂介导的神经炎症和酒精使用障碍（形成、戒断、治疗）之间关系的证据。

结果

在酒精使用障碍患者和动物模型中发现了鞘脂代谢紊乱，包括不同类型的鞘脂和调节酶活性，进而导致中枢神经系统的神经炎症。因此，这些疾病也可能是患者发生酒精使用障碍的重要机制。此外，不同的鞘脂对酒精使用障碍可能有不同甚至相反的作用。

结论

鞘脂介导的神经炎症在酒精使用障碍的发展中起着重要作用。这篇综述提出了一种通过控制鞘脂代谢来预防和治疗酒精使用障碍的潜在方法。