Sickle cell disease is a major public health concern due to its prevalence and associated morbidities. In high-income countries, diagnosis and treatment advancements have extended patient's lives and enabled women to embrace motherhood. Although the provision of care in specialist centres has reduced maternal–fetal complication rates, the mortality rate among pregnant women with sickle cell disease remains disproportionately high. Complications arise from vaso-occlusive events, worsening organ damage, thrombotic risks, infections, and pregnancy-related issues, such as pre-eclampsia, premature birth, small-for-gestational-age, and pregnancy loss. Effective management during pregnancy includes preconception planning, genetic counselling, education, and collaborative care. There is no consensus on the overall approach to managing pregnant women with sickle cell disease; however, fostering a collaborative relationship between health-care professionals and researchers is crucial for advancing the understanding and management of this illness. The disparities in health-care outcomes associated with ethnicity and economic insecurity affect patients with sickle cell disease but have not been examined extensively. Hence, health-care personnel need sufficient training to address these issues alongside broader societal efforts to confront racism and discrimination. Comprehensive national and global action plans are required to address the multifaceted challenges of sickle cell disease.

中文翻译：

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高收入国家镰状细胞病患者妊娠的全面看法：需要可靠的数据以及发病率和死亡率的进一步下降

由于其患病率和相关发病率，镰状细胞病是一个主要的公共卫生问题。在高收入国家，诊断和治疗的进步延长了患者的生命，并使妇女能够成为母亲。尽管专科中心提供的护理降低了母婴并发症的发生率，但患有镰状细胞病的孕妇的死亡率仍然过高。并发症由血管闭塞事件、器官损伤恶化、血栓形成风险、感染和妊娠相关问题（如先兆子痫、早产、小于胎龄和妊娠流产）引起。怀孕期间的有效管理包括孕前计划、遗传咨询、教育和协作护理。对于治疗镰状细胞病孕妇的总体方法尚未达成共识；然而，培养卫生保健专业人员和研究人员之间的合作关系对于增进对这种疾病的理解和管理至关重要。与种族和经济不安全相关的医疗保健结果的差异影响着镰状细胞病患者，但尚未得到广泛研究。因此，卫生保健人员需要足够的培训来解决这些问题，同时需要更广泛的社会努力来对抗种族主义和歧视。需要制定全面的国家和全球行动计划来应对镰状细胞病的多方面挑战。