An experimental technique was developed for the production of tableted nanostructured fibrous enterosorbent for medical applications using a nanostructured activated carbon fiber material of solid-phase pyrolytic origin, created by our research team. The properties of the main active ingredient in the pills, as an effective adsorbing component, were studied. The porous structure parameters were examined with the desiccator method based on the absorption of benzene vapors, while the specific surface area was analyzed with the Brunauer–Emmett–Teller (BET) method. Spectrophotometric methods were employed to determine the concentration of the sorbate in solutions. The microstructure of the samples was studied using a scanning electron microscope (Superprobe-733 X-ray microanalyzer, JEOL, Japan). Energy-dispersive X-ray analysis provided data on the chemical composition and biocompatibility of the samples, serving as an integral indicator. Conditions for the key stages in the enterosorbent production process were experimentally tested. The influence of different types of binders on the process properties of the tablet charge and on the characteristics of test enterosorbent pills was analyzed. The novelty of the developed process was the use of material with special characteristics, promoted by bound carbon nanoforms present in its structure, for enterosorbent production. Improvements in the process operations were proposed, such as decreasing the compaction speed and simultaneously increasing the time the tablet charge was kept under pressure, leading to the redistribution of strains. It was proposed that the compaction process be conducted using punches with a flat surface of purity class 10 to prevent sticking. Therefore, our research team developed tableted enterosorbent with typical features of its main component—nanostructured activated fibrous carbon material—as an effective adsorbent for a relatively wide range of different compounds.

我们的研究团队开发了一种实验技术，使用固相热解来源的纳米结构活性碳纤维材料生产用于医疗应用的片状纳米结构纤维肠吸附剂。研究了丸剂中主要活性成分作为有效吸附成分的性质。采用基于苯蒸气吸收的干燥器法测定多孔结构参数，采用Brunauer-Emmett-Teller (BET)法分析比表面积。采用分光光度法测定溶液中山梨酸盐的浓度。使用扫描电子显微镜（Superprobe-733 X 射线微分析仪，JEOL，日本）研究样品的微观结构。能量色散 X 射线分析提供了样品的化学成分和生物相容性数据，作为一个完整的指标。对肠吸附剂生产过程中关键阶段的条件进行了实验测试。分析了不同类型的粘合剂对片剂装料的工艺性能和试验肠吸附药丸特性的影响。所开发工艺的新颖之处在于使用具有特殊特性的材料，通过其结构中存在的结合碳纳米形式来促进肠吸附剂的生产。提出了工艺操作的改进，例如降低压实速度并同时增加片剂装料在压力下保持的时间，从而导致菌株的重新分布。建议使用具有纯度等级 10 的平坦表面的冲头进行压实过程，以防止粘连。因此，我们的研究团队开发了片状肠道吸附剂，其主要成分——纳米结构活性纤维碳材料——具有典型特征，可作为相对广泛的不同化合物的有效吸附剂。