Each year, SARS-CoV-2 is infecting an increasingly unprecedented number of species. In the present article, we combine mammalian phylogeny with the genetic characteristics of isolates found in mammals to elaborate on the host-range potential of SARS-CoV-2. Infections in nonhuman mammals mirror those of contemporary viral strains circulating in humans, although, in certain species, extensive viral circulation has led to unique genetic signatures. As in other recent studies, we found that the conservation of the ACE2 receptor cannot be considered the sole major determinant of susceptibility. However, we are able to identify major clades and families as candidates for increased surveillance. On the basis of our findings, we argue that the use of the term panzootic could be a more appropriate term than pandemic to describe the ongoing scenario. This term better captures the magnitude of the SARS-CoV-2 host range and would hopefully inspire inclusive policy actions, including systematic screenings, that could better support the management of this worldwide event.

中文翻译：

---

SARS-CoV-2 的泛动物潜力

每年，SARS-CoV-2 感染的物种数量都前所未有。在本文中，我们将哺乳动物系统发育与哺乳动物中发现的分离株的遗传特征相结合，详细阐述了 SARS-CoV-2 的宿主范围潜力。非人类哺乳动物中的感染反映了人类中传播的当代病毒株的感染，尽管在某些物种中，广泛的病毒传播导致了独特的遗传特征。与最近的其他研究一样，我们发现 ACE2 受体的保守性不能被视为易感性的唯一主要决定因素。然而，我们能够确定主要的进化枝和科作为加强监测的候选者。根据我们的研究结果，我们认为使用“泛动物”一词可能比“大流行”更适合描述当前的情况。该术语更好地反映了 SARS-CoV-2 宿主范围的规模，并有望激发包容性政策行动，包括系统筛查，从而更好地支持这一全球性事件的管理。