Cerebellar amyloid-β (Aβ) plaques are a component of the diagnostic criteria used in Thal staging and ABC scoring for Alzheimer disease (AD) neuropathologic change. However, Aβ deposits in this anatomic compartment are unique and under-characterized; and their relationship with other pathological findings are largely undefined. In 73 cases of pure or mixed AD with an A3 score in the ABC criteria, parenchymal (plaques) and vascular (cerebral amyloid angiopathy [CAA]) cerebellar Aβ-42 deposits were characterized with respect to localization, morphology, density, and intensity. Over 85% of cases demonstrated cerebellar Aβ-42 parenchymal staining that correlated with a Braak stage V-VI/B3 score (p < 0.01). Among the 63 with cerebellar Aβ-42 deposits, a diffuse morphology was observed in 75% of cases, compact without a central dense core in 32%, and compact with a central dense core in 16% (all corresponding to plaques evident on hematoxylin and eosin staining). Cases with Purkinje cell (PC) loss showed higher proportions of PC layer Aβ-42 staining than cases without PC loss (88% vs 44%, p = 0.02), suggesting a link between Aβ-42 deposition and PC damage. Among all 73 cases, CAA was observed in the parenchymal vessels of 19% of cases and in leptomeningeal vessels in 44% of cases.

中文翻译：

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阿尔茨海默病中小脑淀粉样蛋白-β沉积物的特征

小脑淀粉样蛋白-β (Aβ) 斑块是阿尔茨海默病 (AD) 神经病理改变的 Thal 分期和 ABC 评分中使用的诊断标准的组成部分。然而，该解剖室中的 Aβ 沉积物是独特的且特征不足；它们与其他病理结果的关系在很大程度上尚不清楚。在 73 例 ABC 标准中评分为 A3 的纯 AD 或混合 AD 病例中，对实质（斑块）和血管（脑淀粉样血管病 [CAA]）小脑 Aβ-42 沉积物的定位、形态、密度和强度进行了表征。超过 85% 的病例表现出小脑 Aβ-42 实质染色，与 Braak V-VI/B3 期评分相关（p < 0.01）。在 63 个有小脑 Aβ-42 沉积的病例中，75% 的病例观察到弥漫性形态，32% 的病例观察到致密无中央致密核，16% 的病例致密有中央致密核（全部对应于苏木精和伊红染色）。浦肯野细胞 (PC) 丢失的病例显示 PC 层 Aβ-42 染色比例高于 PC 未丢失的病例（88% vs 44%，p = 0.02），表明 Aβ-42 沉积与 PC 损伤之间存在联系。在所有 73 例病例中，19% 的病例在实质血管中观察到 CAA，44% 的病例在软脑膜血管中观察到 CAA。