The main obstacle to applying aluminum oxide doped with carbon and magnesium (Al₂O₃:C,Mg)-based fluorescent nuclear track detectors (FNTDs) in radionuclide therapy with alpha emitters is that it has not been known how to achieve an accurate and in situ dose assessment for in vitro cellular experiments. In this study, we developed an automatic 3D track reanalysis algorithm (ATRA) to analyze the alpha energy spectra in FNTDs. The algorithm provides an excellent track identification rate and an excellent track linking rate (0.961) without significant variations in various track densities. The algorithm also achieves a reliable track detection rate exceeding 0.927 for track densities at the level of in situ measurement, and it successfully measures the alpha energy spectra for obtaining the absorbed dose. We also confirmed that the track overlap clearly interferes with accurate track reconstruction for track densities beyond 1.5 × 10⁶ tracks cm⁻². We provided a correction equation that can be used to obtain the actual alpha tracks for high track densities; the equation may also correct estimations of absorbed doses due to alpha particles.

将碳和镁掺杂的氧化铝 (Al ₂ O ₃ :C,Mg) 基荧光核径迹探测器 (FNTD) 应用到 α 发射体放射性核素治疗中的主要障碍是，尚不知道如何实现准确且可靠的检测。体外细胞实验的原位剂量评估。在这项研究中，我们开发了一种自动 3D 轨迹再分析算法 (ATRA) 来分析 FNTD 中的 α 能谱。该算法提供了优异的轨迹识别率和优异的轨迹链接率（0.961），并且在各种轨迹密度下没有显着变化。该算法还实现了原位测量水平的径迹密度超过0.927的可靠径迹检测率，并成功测量了α能谱以获得吸收剂量。我们还证实，轨道重叠明显干扰轨道密度超过1.5 × 10 ⁶轨道cm ^-2的精确轨道重建。我们提供了一个校正方程，可用于获取高磁道密度的实际 alpha 磁道；该方程还可以修正对α粒子吸收剂量的估计。