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Adrenergic signaling dampens T cell activity during chronic infection and cancer
Trends in Neurosciences ( IF 15.9 ) Pub Date : 2023-12-20 , DOI: 10.1016/j.tins.2023.12.001
Maureen A. Cox

Stress contributes to infection and cancer susceptibility, but the mediating mechanisms are still being elucidated. CD8 T cells are critical players in antiviral and antitumor immune responses. A recent study by together with a growing body of literature, link norepinephrine produced during the stress response to CD8 T cell dysfunction.

中文翻译:

肾上腺素信号传导抑制慢性感染和癌症期间的 T 细胞活性

压力会导致感染和癌症易感性,但其介导机制仍有待阐明。CD8 T 细胞在抗病毒和抗肿瘤免疫反应中发挥着关键作用。最近的一项研究以及越来越多的文献将应激反应过程中产生的去甲肾上腺素与 CD8 T 细胞功能障碍联系起来。
更新日期:2023-12-20
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