As the most prevalent and reversible internal epigenetic modification in eukaryotic mRNAs, N⁶-methyladenosine (m⁶A) post-transcriptionally regulates the processing and metabolism of mRNAs involved in diverse biological processes. m⁶A modification is regulated by m⁶A writers, erasers, and readers. Emerging evidence suggests that m⁶A modification plays essential roles in modulating the cell fate transition of embryonic stem cells. Mechanistic investigation of embryonic stem cell maintenance and differentiation is critical for understanding early embryonic development, which is also the premise for the application of embryonic stem cells in regenerative medicine. This review highlights the current knowledge of m⁶A modification and its essential regulatory contribution to the cell fate transition of mouse and human embryonic stem cells.

作为真核 mRNA 中最普遍且可逆的内部表观遗传修饰，N⁶-甲基腺苷 ( m⁶A) 转录后调节参与多种生物过程的 mRNA 的加工和代谢。 m⁶修改由 m⁶书写器、橡皮擦、和读者。新的证据表明，m⁶A 修饰在调节胚胎干细胞的细胞命运转变中发挥着重要作用。胚胎干细胞维持和分化的机制研究对于理解早期胚胎发育至关重要，这也是胚胎干细胞在再生医学中应用的前提。本综述重点介绍了 m⁶A 修饰的最新知识及其对小鼠和人类胚胎干细胞细胞命运转变的重要调节作用。