Abstract Tim-3 is a transmembrane protein that is best known for being highly expressed on terminally exhausted CD8+ T cells associated with chronic infection and tumors, although its expression is not limited to those settings. Tim-3 is also expressed by CD8+ T cells during acute infection and by multiple other immune cell types, including CD4+ Th1 and regulatory T cells, dendritic cells, and mast cells. In this study, we investigated the role of Tim-3 signaling on CD8+ T cell memory using a Tim-3 conditional knockout mouse model and mice lacking the signaling portion of the Tim-3 cytoplasmic domain. Together, our results indicate that Tim-3 has at most a modest effect on the formation and function of CD8+ memory T cells.

中文翻译：

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建立 CD8+ T 细胞对淋巴细胞性脉络膜脑膜炎病毒的记忆不需要 Tim-3

摘要Tim-3 是一种跨膜蛋白，最著名的是在与慢性感染和肿瘤相关的终末耗竭的 CD8+ T 细胞上高表达，尽管它的表达并不限于这些情况。Tim-3 还在急性感染期间由 CD8+ T 细胞和多种其他免疫细胞类型表达，包括 CD4+ Th1 和调节性 T 细胞、树突状细胞和肥大细胞。在这项研究中，我们使用 Tim-3 条件敲除小鼠模型和缺乏 Tim-3 细胞质结构域信号部分的小鼠研究了 Tim-3 信号传导对 CD8+ T 细胞记忆的作用。总之，我们的结果表明 Tim-3 对 CD8+ 记忆 T 细胞的形成和功能至多具有适度的影响。