Single-cell data and computational simulations reveal the dynamics of the transcription factors HIF1α and PPARγ during adipocyte differentiation and maturation. Modeling feedback within this network predicts a HIF1α-mediated choice between lipid accumulation and incomplete differentiation. In vitro experiments support this model, with implications for adipose dynamics in metabolic disorders involving hypoxia.

中文翻译：

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建模阐明了脂肪调节的背景依赖性

单细胞数据和计算模拟揭示了脂肪细胞分化和成熟过程中转录因子 HIF1α 和 PPARγ 的动态。该网络内的反馈建模预测了 HIF1α 介导的脂质积累和不完全分化之间的选择。体外实验支持这一模型，对涉及缺氧的代谢紊乱中的脂肪动力学具有影响。