Gastric cancer (GC) is currently the fifth most common malignancy. Accumulating evidence has recently revealed that maladjustments of diverse long non-coding RNAs may play key roles in multiple genetic and epigenetic phenomena in GC. Long non-coding RNAs (lncRNAs), which are transcriptional products with more than 200 nucleotides, are a subset of non-coding RNAs. LncRNA LOWEG and lncRNA MINCR, as novel lncRNAs, may have roles in GC progression. This study aimed to examine the clinical and diagnostic significance of lncRNA LOWEG and lncRNA MINCR in GC. The qRT-PCR technique measured lncRNA LOWEG and lncRNA MINCR expression in GC tissues and matched adjacent marginal tissues. The association between clinicopathological parameters and the expression level of lncRNAs was evaluated. Furthermore, The ROC curve was plotted to assess the diagnostic power of lncRNA LOWEG and lncRNA MINCR as candidate biomarkers in gastric cancer patients. We found that lncRNA LOWEG expression was downregulated in cancerous tissues compared to the adjacent marginal tissues (P-value < 0.0001). LncRNA MINCR expression was upregulated in cancerous tissues compared to adjacent marginal tissues (P-value < 0.0001). Downregulation of lncRNA LOWER and upregulation of lncRNA MINCR did not significantly correlate with clinicopathological parameters. ROC curve analysis showed that lncRNA LOWEG and lncRNA MINCR could be proposed as reliable diagnostic biomarkers in GC. The expression of the lncRNA LOWEG was reduced in tumoral tissues compared to the adjacent marginal tissues, and the expression of lncRNA MINCR increased in tumoral tissues. So, as a result, lncRNAs LOWEG and MINCR could be considered diagnostic biomarkers for GC.

中文翻译：

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长链非编码RNA LOWEG和MINCR在人胃癌中的表达及其临床意义的评估

胃癌（GC）目前是第五大常见恶性肿瘤。最近越来越多的证据表明，多种长非编码RNA的失调可能在GC的多种遗传和表观遗传现象中发挥关键作用。长非编码 RNA (lncRNA) 是具有 200 多个核苷酸的转录产物，是非编码 RNA 的一个子集。LncRNA LOWEG 和 lncRNA MINCR 作为新型 lncRNA，可能在 GC 进展中发挥作用。本研究旨在探讨 lncRNA LOWEG 和 lncRNA MINCR 在 GC 中的临床和诊断意义。qRT-PCR 技术测量了 GC 组织和匹配的邻近边缘组织中的 lncRNA LOWEG 和 lncRNA MINCR 表达。评估临床病理参数与lncRNA表达水平之间的关联。此外，绘制 ROC 曲线以评估 lncRNA LOWEG 和 lncRNA MINCR 作为胃癌患者候选生物标志物的诊断能力。我们发现，与邻近边缘组织相比，癌组织中 lncRNA LOWEG 表达下调（P 值 < 0.0001）。与邻近边缘组织相比，癌组织中 LncRNA MINCR 表达上调（P 值 < 0.0001）。lncRNA LOWER 的下调和 lncRNA MINCR 的上调与临床病理参数没有显着相关性。ROC 曲线分析表明，lncRNA LOWEG 和 lncRNA MINCR 可以作为 GC 的可靠诊断生物标志物。与邻近边缘组织相比,肿瘤组织中lncRNA LOWEG的表达量减少,lncRNA MINCR在肿瘤组织中的表达量增加。因此，lncRNA LOWEG 和 MINCR 可以被视为 GC 的诊断生物标志物。