& Learning Objectives:Improvements in treatment for non-CNS cancer have greatly improved survivorship, allowing increased attention to cancer- and treatment-related sequelae. Cognitive symptoms (cancer-related cognitive impairment, or CRCI) are reported by a large percentage of cancer survivors, and can have a clinically meaningful impact on educational, vocational, and social functioning, and thus overall quality of life. Better understanding of these concerns is therefore of critical importance, and is needed to guide treatment and potential prevention strategies. Neuropsychological studies over the past 40 years have demonstrated cognitive domains commonly affected in cancer patients treated with chemotherapy, but have also shown cognitive differences in patients not treated with systemic therapy and those receiving other types of treatment (e.g., hormonal therapies) relative to non-cancer control groups. More recently, structural and functional neuroimaging research has added to our understanding of the neural substrate of these cognitive symptoms. This course will describe various neuroimaging modalities used to investigate CRCI, including examination of grey and white matter volume and structural integrity, blood flow, brain activation during cognitive processing and at rest, and structural and functional connectivity. The presentation will also review how neuroimaging findings relate to objective and self-reported cognition and clinical and treatment factors, and discuss potential approaches currently being investigated to treat CRCI. Upon conclusion of this course, learners will be able to:1.Explain commonly affected cognitive domains after non-CNS cancer and treatment2.Discuss structural and functional brain changes related to cancer, chemotherapy, and other treatments3.Describe treatment interventions being investigated to treat cancer- and treatment-related cognitive symptoms.

中文翻译：

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CE 研讨会 07：癌症和治疗的认知影响：“Chemobrain”及其他

& 学习目标：非中枢神经系统癌症治疗的改进极大地提高了生存率，使人们更加关注癌症和治疗相关的后遗症。大多数癌症幸存者都报告有认知症状（癌症相关认知障碍，CRCI），并且可能对教育、职业和社会功能以及整体生活质量产生具有临床意义的影响。因此，更好地了解这些问题至关重要，并且需要指导治疗和潜在的预防策略。过去 40 年的神经心理学研究表明，接受化疗的癌症患者的认知领域通常会受到影响，但也表明，未接受全身治疗的患者和接受其他类型治疗（例如激素疗法）的患者相对于非化疗患者的认知存在差异。癌症对照组。最近，结构和功能神经影像学研究增加了我们对这些认知症状的神经基础的理解。本课程将描述用于研究 CRCI 的各种神经影像学模式，包括灰质和白质体积和结构完整性、血流、认知处理和休息期间的大脑激活以及结构和功能连接的检查。该演讲还将回顾神经影像学结果如何与客观和自我报告的认知以及临床和治疗因素相关，并讨论目前正在研究的治疗 CRCI 的潜在方法。完成本课程后，学习者将能够：1.解释非中枢神经系统癌症和治疗后常见受影响的认知领域2.讨论与癌症、化疗和其他治疗相关的大脑结构和功能变化3.描述正在研究的治疗癌症和治疗相关认知症状的治疗干预措施。