Purpose

This study measured bone mineral density (BMD) in a Japanese population using the novel non-ionizing system using radiofrequency echographic multispectrometry (REMS) and compared the results with those obtained using traditional dual-energy X-ray absorptiometry (DXA). We aimed to identify any discrepancies between measurements obtained using these instruments and identify the influencing factors.

Methods

This cross-sectional study examined patients with osteoporosis treated at a single center from April to August 2023. We examined BMD assessment by DXA and REMS in lumbar spine and proximal femur. Patients were categorized into two groups: those with discrepancies between lumbar spine BMD measured by DXA and REMS, and those without. Semiquantitative evaluation of vertebral fractures and abdominal aortic calcification scoring were also performed and compared between the two groups, along with various patient characteristics.

Results

A total of 70 patients (88.6% female; mean age 78.39 ± 9.50 years) undergoing osteoporosis treatment were included in the study. A significant difference was noted between DXA and REMS measurement of BMD and T-scores, with REMS recording consistently lower values. The discrepancy group exhibited a higher incidence of multiple vertebral fractures and increased vascular calcification than the non-discrepancy group. Multivariate analysis indicated that diabetes mellitus, severe vertebral fractures, and increased abdominal aortic calcification scores were significantly associated with discrepancies in lumbar spine T-scores.

Conclusion

This study suggests that REMS may offer a more accurate measurement of BMD, overcoming the overestimation of BMD by DXA owing to factors such as vertebral deformities, abdominal aortic calcification, and diabetes mellitus.

中文翻译：

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射频回波多谱测量（REMS）可以克服结构性内部伪影的影响并准确评估骨脆性

目的

本研究使用射频回波多光谱法 (REMS) 的新型非电离系统测量了日本人群的骨矿物质密度 (BMD)，并将结果与​​使用传统双能 X 射线吸收测定法 (DXA) 获得的结果进行了比较。我们的目的是找出使用这些仪器获得的测量结果之间的任何差异，并确定影响因素。

方法

这项横断面研究调查了 2023 年 4 月至 8 月在单一中心接受治疗的骨质疏松症患者。我们检查了 DXA 和 REMS 对腰椎和股骨近端的 BMD 评估。患者被分为两组：DXA 和 REMS 测量的腰椎 BMD 存在差异的组，以及没有差异的组。还对两组之间的椎骨骨折和腹主动脉钙化评分进行半定量评估，并比较不同的患者特征。

结果

该研究共纳入 70 名接受骨质疏松症治疗的患者（88.6% 为女性；平均年龄 78.39 ± 9.50 岁）。DXA 和 REMS 测量的 BMD 和 T 分数之间存在显着差异，REMS 记录的值始终较低。差异组比非差异组表现出更高的多发椎体骨折发生率和血管钙化增加。多变量分析表明，糖尿病、严重椎骨骨折和腹主动脉钙化评分增加与腰椎 T 评分差异显着相关。

结论

这项研究表明，REMS 可以提供更准确的 BMD 测量，克服 DXA 由于椎骨畸形、腹主动脉钙化和糖尿病等因素对 BMD 的高估。