Helicobacter pylori infection is a prevalent global infection associated with several complications such as peptic ulcer, upper gastrointestinal bleeding, and stomach cancer. An imbalance in the gut microbiota composition or the relationship between the microbiota and the host may be implicated in the infection. To investigate this, we studied the intestinal microbiota of 50 newly infected adolescents with H. pylori compared with 50 age-matched and sex-matched healthy controls. The gut microbiota composition was assessed using real-time polymerase chain reaction (RT-PCR), and the fecal bacterial diversity and composition were compared between groups. Our findings revealed that Clostridium difficile and Salmonella spp. were significantly higher in the patient group compared to the control group. Additionally, lower counts of eubacteria, Bacteroides fragilis, Lactobacillus spp., Escherichia coli, and Methanobrevibacter smithii, were observed in the gut of adolescents with H. pylori. Conversely, adolescents with H. pylori infection had non-significantly higher counts of Bifidobacterium spp., C. difficile, and Salmonella spp. Multiple logistic regression analysis revealed that a greater abundance of Bifidobacterium spp. and Salmonella spp., a higher prevalence of C. difficile, and a lower abundance of Lactobacillus spp. were predictive of H. pylori infection. Overall, our results suggest that H. pylori infection is associated with changes in fecal microbiome composition.

幽门螺杆菌感染是一种普遍的全球感染，与消化性溃疡、上消化道出血和胃癌等多种并发症相关。肠道微生物群组成或微生物群与宿主之间关系的不平衡可能与感染有关。为了调查这一点，我们研究了 50 名新感染幽门螺杆菌青少年的肠道微生物群，并与 50 名年龄匹配和性别匹配的健康对照者进行比较。使用实时聚合酶链反应（RT-PCR）评估肠道微生物群组成，并比较各组之间的粪便细菌多样性和组成。我们的研究结果表明，艰难梭菌和沙门氏菌。与对照组相比，患者组明显升高。此外，在患有幽门螺杆菌的青少年肠道中观察到真细菌、脆弱拟杆菌、乳杆菌、大肠杆菌和史密斯甲烷短杆菌的数量较低。相反，感染幽门螺杆菌的青少年的双歧杆菌计数并未显着升高。、艰难梭菌和沙门氏菌。多元逻辑回归分析显示，双歧杆菌属的丰度更高。和沙门氏菌，艰难梭菌的患病率较高，而乳杆菌的丰度较低。可以预测幽门螺杆菌感染。总体而言，我们的结果表明幽门螺杆菌感染与粪便微生物组组成的变化有关。