To regulate biological activity in humans, the Notch signaling pathway (NSP) plays an essential role in a wide array of cellular development and differentiation process. In recent years, many studies have reported that aberrant activation of Notch is associated with the tumor process; but no appropriate database exists to fill this significant gap. To address this, we created a pioneering database NCSp, which is open access and comprises intercommunicating pathways and related protein mutations. This allows scientists to understand better the cause of single amino acid mutations in proteins. Therefore, NCSp provides information on the predicted functional effect of human protein mutations, which aids in understanding the importance of mutations linked to the Notch crosstalk signaling pathways in cancerous and non-cancerous systems. This database might be helpful for therapeutic mutation analysis, molecular biology, and structural biology researchers. The NCSp database can be accessed through https://bioserver3.physics.iisc.ac.in/cgi-bin/nccspd/.

为了调节人类的生物活性，Notch 信号通路 (NSP) 在多种细胞发育和分化过程中发挥着重要作用。近年来，许多研究报道Notch的异常激活与肿瘤的发生过程有关；但不存在合适的数据库来填补这一重大空白。为了解决这个问题，我们创建了一个开创性的数据库 NCSp，该数据库是开放访问的，包含互通途径和相关蛋白质突变。这使得科学家能够更好地了解蛋白质中单个氨基酸突变的原因。因此，NCSp 提供了有关人类蛋白质突变的预测功能效应的信息，这有助于了解与癌性和非癌性系统中 Notch 串扰信号通路相关的突变的重要性。该数据库可能对治疗突变分析、分子生物学和结构生物学研究人员有所帮助。NCSp 数据库可以通过 https://bioserver3.physicals.iisc.ac.in/cgi-bin/nccspd/ 访问。