The membrane protein CD36 is a lipid transporter, scavenger receptor, and receptor for the antiangiogenic protein thrombospondin 1 (TSP1). CD36 is expressed by cancer cells and by many associated cells including various cancer-infiltrating immune cell types. Thereby, CD36 plays critical roles in cancer, and it has been reported to affect cancer growth, metastasis, angiogenesis, and drug resistance. However, these roles are partly contradictory, as CD36 has been both reported to promote and inhibit cancer progression. Moreover, the mechanisms are also partly contradictory, because CD36 has been shown to exert opposite cellular effects such as cell division, senescence and cell death. This review provides an overview of the diverse effects of CD36 on tumor progression, aiming to shed light on its diverse pro- and anti-cancer roles, and the implications for therapeutic targeting.

膜蛋白 CD36 是一种脂质转运蛋白、清道夫受体和抗血管生成蛋白血小板反应蛋白 1 (TSP1) 的受体。CD36 由癌细胞和许多相关细胞（包括各种癌症浸润免疫细胞类型）表达。因此，CD36 在癌症中发挥着关键作用，据报道它会影响癌症的生长、转移、血管生成和耐药性。然而，这些作用在一定程度上是矛盾的，因为据报道 CD36 既能促进又能抑制癌症进展。此外，这些机制也部分矛盾，因为 CD36 已被证明发挥相反的细胞作用，如细胞分裂、衰老和细胞死亡。本综述概述了 CD36 对肿瘤进展的多种影响，旨在阐明其多种促癌和抗癌作用，以及对治疗靶向的影响。