We aim to compare the outcomes in patients with atrial fibrillation detected after stroke (AFDAS) and their counterparts with known AF (KAF) presenting with large vessel occlusion (LVO) treated with mechanical thrombectomy (MT). This observational, prospective study included consecutive patients with acute LVO ischemic stroke of the anterior circulation with AFDAS, KAF and without AF. The primary study outcome was functional independence at 90 days after stroke. The secondary study outcomes were variation of the NIHSS score at 24 h, rate of successful reperfusion, death at 90 days and rate of immediate complications post-procedure. Overall, our cohort included 518 patients with acute ischemic stroke and LVO treated with MT, with 289 (56.8%) without a diagnosis of AF; 107 (21%) with AFDAS; 122 (22.2%) with KAF. There was no significant difference in terms of functional independence at 90 days after stroke between the three groups. Regarding the secondary study outcome, the rate of symptomatic intracranial haemorrhage (sICH) and/or parenchymal hematoma (PH) were significantly higher in the group of patients without AF (respectively, P = 0.030 and < 0.010). Logistic regression analysis showed that the subtypes of AF were not statistically significantly associated with functional independence at 90 days after stroke and with the likelihood of any ICH. Our results suggest that the subtypes of AF are not associated with clinical and safety outcomes of MT in patients with acute stroke and LVO. Further studies are needed to confirm our findings.

我们的目的是比较中风后检测到的房颤患者 (AFDAS) 和已知 AF 患者 (KAF) 的结果，并通过机械血栓切除术 (MT) 治疗出现大血管闭塞 (LVO)。这项观察性、前瞻性研究纳入了患有 AFDAS、KAF 和不患有 AF 的连续急性 LVO 前循环缺血性卒中患者。主要研究结果是中风后 90 天的功能独立性。次要研究结果是 24 小时 NIHSS 评分的变化、再灌注成功率、90 天死亡率以及术后即时并发症发生率。总体而言，我们的队列包括 518 名接受 MT 治疗的急性缺血性中风和 LVO 患者，其中 289 名 (56.8%) 没有诊断为 AF；107 (21%) 与 AFDAS 合作；122 (22.2%) 与 KAF 合作。中风后 90 天，三组之间的功能独立性没有显着差异。关于次要研究结果，无 AF 患者组中症状性颅内出血 (sICH) 和/或实质血肿 (PH) 的发生率显着较高（分别为P  = 0.030 和 < 0.010）。Logistic 回归分析显示，AF 亚型与卒中后 90 天的功能独立性以及任何 ICH 的可能性没有统计学显着相关性。我们的结果表明，AF 亚型与急性卒中和 LVO 患者的 MT 临床和安全性结果无关。需要进一步的研究来证实我们的发现。