The increasing aging of the human population is currently and for the coming decades a major public health issue in many countries, requiring the implementation of global public health policies promoting healthy and successful aging. Individuals are not equal in the face of aging and some can present exceptional healthspan and/or lifespan, which are notably influenced by both genetic and environmental factors. Research and studies on human aging, healthy aging and longevity should rely in particular on cohorts of long-lived individuals, also including biological samples allowing studies on the biology of aging and longevity. In this manuscript, we provide for the first time a complete description of the CEPH (Centre d’Etude du Polymophisme Humain) Aging cohort, an exceptional cohort recruited during the 90s to 2000s, including more than 1700 French long-lived individuals (≥ 90 years old) born between 1875 and 1916 as well as for some of them their siblings and offspring. Among the participants, 1265 were centenarians, including 255 semi-supercentenarians ([105–110] years old) and 25 supercentenarians (≥ 110 years old). The available anthropometric, epidemiologic and clinical data for the cohort participants are described and especially the collection of blood-derived biological samples associated with the cohort which includes DNA, cryopreserved cells and cell lines, plasma, and serum. This biological collection from the first cohort of centenarians in the world is an inestimable resource for ongoing and future molecular, cellular, and functional studies aimed at deciphering the mechanisms of human (successful) aging and longevity.

人口老龄化加剧是当前和未来几十年许多国家的一个重大公共卫生问题，需要实施促进健康和成功老龄化的全球公共卫生政策。面对衰老，个体是不平等的，有些人可以表现出出色的健康寿命和/或寿命，这主要受到遗传和环境因素的影响。关于人类衰老、健康衰老和长寿的研究应特别依赖于长寿个体群体，还包括可以对衰老和长寿生物学进行研究的生物样本。在这份手稿中，我们首次提供了 CEPH（Centre d'Etude du Polymophisme Humain）老龄化队列的完整描述，这是一个在 90 年代至 2000 年代招募的特殊队列，包括 1700 多名法国长寿个体（≥ 90岁）出生于 1875 年至 1916 年之间，其中一些人还包括他们的兄弟姐妹和后代。参与者中，百岁老人1265人，其中半百岁老人（[105-110]岁）255人，超级百岁老人（≥110岁）25人。描述了队列参与者可用的人体测量、流行病学和临床数据，特别是与队列相关的血液来源的生物样本的收集，其中包括 DNA、冷冻保存的细胞和细胞系、血浆和血清。来自世界上第一批百岁老人的生物收藏对于正在进行和未来旨在破译人类（成功）衰老和长寿机制的分子、细胞和功能研究来说是不可估量的资源。