Estimating and evaluating the inherent safety of processes pose a significant challenge in the field of inherent safety. Indicators are commonly employed tools to address this challenge. However, one of the weaknesses of risk-based indicators is their assumption of equal weight and importance for all indicators, despite the fact that the impact of each indicator may vary. This study aimed to investigate whether assigning weights to indicators can enhance the performance of inherent safety indices. To achieve this objective, all indicators that influence inherent safety were identified through systematic literature review and expert interviews. Subsequently, the final weights of these indicators were determined using multicriteria decision-making methods such as BWM, DEMATEL, and fuzzy ANP. By integrating these indicators, a Weighted Inherent Safety Index (WISI) was developed, accompanied by two subsidiary inherent safety indices: process inherent safety (consisting of 5 indicators) and chemical material inherent safety (consisting of 9 indicators). The WISI index serves as a quantitative measure to assess various synthesis routes of a chemical substance and determine the safer option during the conceptual design phase. In a case study, the production process of methyl methacrylate involving 6 different synthesis routes was selected, and the WISI index was applied to validate its effectiveness. Overall, this approach introduces a novel perspective to enhance the performance of inherent safety indices by assigning appropriate weights to indicators, thereby promoting a more comprehensive evaluation of process safety.

估计和评估过程的固有安全性在本质安全领域提出了重大挑战。指标是应对这一挑战的常用工具。然而，基于风险的指标的弱点之一是它们假设所有指标的权重和重要性相同，尽管每个指标的影响可能有所不同。本研究旨在探讨为指标分配权重是否可以提高本质安全指数的绩效。为了实现这一目标，通过系统的文献回顾和专家访谈，确定了影响本质安全的所有指标。随后，利用BWM、DEMATEL、模糊ANP等多准则决策方法确定这些指标的最终权重。通过整合这些指标，制定了加权本质安全指数（WISI），并附有两个附属本质安全指数：过程本质安全（由5个指标组成）和化学材料本质安全（由9个指标组成）。WISI指数作为一种定量指标，用于评估化学物质的各种合成路线，并在概念设计阶段确定更安全的选择。以案例研究为例，选取涉及6条不同合成路线的甲基丙烯酸甲酯生产工艺，并应用WISI指数验证其有效性。总体而言，该方法引入了一种新颖的视角，通过为指标分配适当的权重来提高本质安全指标的性能，从而促进对过程安全进行更全面的评估。