Background

Cervical cancer, a pernicious gynecological malignancy, causes the mortality of hundreds of thousands of females worldwide. Despite a considerable decline in mortality, the surging incidence rate among younger women has raised serious concerns. Immortality is the most important characteristic of tumor cells, hence the carcinogenesis of cervical cancer cells pivotally requires compromising with cell death mechanisms.

Methods

The current study comprehensively reviewed the mechanisms of non-apoptotic cell death programs to provide possible disease management strategies.

Results

Comprehensive evidence has stated that focusing on necroptosis, pyroptosis, and autophagy for disease management is associated with significant limitations such as insufficient understanding, contradictory functions, dependence on disease stage, and complexity of intracellular pathways. However, ferroptosis represents a predictable role in cervix carcinogenesis, and ferroptosis-related genes demonstrate a remarkable correlation with patient survival and clinical outcomes.

Conclusion

Ferroptosis may be an appropriate option for disease management strategies from predicting prognosis to treatment.

中文翻译：

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宫颈癌的非凋亡细胞死亡计划，重点是铁死亡

背景

宫颈癌是一种恶性妇科恶性肿瘤，导致全世界数十万女性死亡。尽管死亡率大幅下降，但年轻女性发病率的飙升引起了严重关注。永生性是肿瘤细胞最重要的特征，因此宫颈癌细胞的癌变关键需要损害细胞死亡机制。

方法

目前的研究全面回顾了非凋亡细胞死亡程序的机制，以提供可能的疾病管理策略。

结果

综合证据表明，在疾病管理中关注坏死性凋亡、细胞焦亡和自噬与重大局限性相关，例如理解不足、功能矛盾、对疾病阶段的依赖以及细胞内途径的复杂性。然而，铁死亡在子宫颈癌发生中具有可预测的作用，并且铁死亡相关基因显示出与患者生存和临床结果显着相关。

结论

铁死亡可能是从预测预后到治疗的疾病管理策略的合适选择。