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NMR-based stability evaluation of (E)-1-(3′,4′-dimethoxyphenyl)butadiene (DMPBD) from Zingiber cassumunar Roxb. rhizome
Phytochemical Analysis ( IF 3.3 ) Pub Date : 2023-12-22 , DOI: 10.1002/pca.3314
Boonwiset Seaho 1 , Chatkamon Lekwongphaiboon 1 , Wichayasith Inthakusol 2, 3 , Saisuree Prateeptongkum 1 , Wacharee Harnying 4 , Albrecht Berkessel 4 , Nongnaphat Duangdee 2, 3
Affiliation  

The active compound (E)-1-(3′,4′-dimethoxyphenyl)butadiene (DMPBD) isolated from the rhizomes of Zingiber cassumunar Roxb. has potent anti-inflammatory and anticancer activities. Although DMPBD is one of the promising drug candidates for phytomedicine, its limited stability impedes its widespread use. For the development of new drugs, the assessment of their chemical stability is essential, ensuring they maintain their properties within specified limits throughout the period from production until use.

中文翻译:

基于 NMR 的 Zingiber cassumunar Roxb 的 (E)-1-(3',4'-二甲氧基苯基)丁二烯 (DMPBD) 稳定性评估。根茎

从Zingiber cassumunar Roxb的根茎中分离得到活性化合物 ( E )-1-(3',4'-二甲氧基苯基)丁二烯 (DMPBD)。具有有效的抗炎和抗癌活性。尽管 DMPBD 是植物医学有前途的候选药物之一,但其有限的稳定性阻碍了其广泛使用。对于新药的开发,对其化学稳定性的评估至关重要,以确保它们从生产到使用的整个过程中将其特性保持在规定的范围内。
更新日期:2023-12-22
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