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Divergent Pattern of Development in Rats and Humans
Neurotoxicity Research ( IF 3.7 ) Pub Date : 2023-12-26 , DOI: 10.1007/s12640-023-00683-y
Wanda Campos Eusebi , Tomas Iorii , Antonella Presti , Rafael Grimson , Pablo Vázquez-Borsetti

Rattus norvegicus is the second most used laboratory species and the most widely used model in neuroscience. Nonetheless, there is still no agreement regarding the temporal relationship of development between humans and rats. We addressed this question by examining the time required to reach a set of homologous developmental milestones in both species. With this purpose, a database was generated with data collected through a bibliographic survey. This database was in turn compared with other databases about the same topic present in the literature. Finally, the databases were combined, covering for the first time the entire development of the rat including the prenatal, perinatal, and postnatal periods. This combined database includes 362 dates of 181 developmental events for each species. The developmental relationship between humans and rats was better fit by a logarithmic function than by a linear function. As development progresses, an increase in the dispersion of the data is observed. Developmental relationships should not be interpreted as a univocal equivalence. In this work is proposed an alternative interpretation where the age of one species is translated into a range of ages in the other.



中文翻译:

大鼠和人类的不同发育模式

褐家鼠是第二大使用的实验室物种,也是神经科学中使用最广泛的模型。尽管如此,关于人类和老鼠之间发育的时间关系仍然没有达成一致。我们通过检查两个物种达到一组同源发育里程碑所需的时间来解决这个问题。为此,通过书目调查收集的数据生成了一个数据库。进而将该数据库与文献中存在的相同主题的其他数据库进行比较。最后,数据库被合并,首次涵盖了大鼠的整个发育过程,包括产前、围产期和产后时期。该综合数据库包含每个物种 181 个发育事件的 362 个日期。人类和大鼠之间的发育关系用对数函数比用线性函数更适合。随着开发的进展,我们观察到数据分散性的增加。发展关系不应被解释为单义的对等。这项工作提出了另一种解释,其中一个物种的年龄被翻译成另一个物种的年龄范围。

更新日期:2023-12-26
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