Intestinal fungi, which are important parts of the gut microbiota, have the ability to produce specialized metabolites that significantly contribute to maintaining the balance of the gut microbiota and promoting the health of the host organism. In the present study, two new glycosides, including fusintespyrone A (1) and cerevisterolside A (4), as well as ten known compounds were isolated from the intestinal fungus Fusarium sp. LE06. The structures of the new compounds were elucidated by a combination of spectroscopic methods, such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), along with chemical reactions and calculations of NMR and ECD spectra. Compounds 1–3 showed significant growth inhibition against Aspergillus fumigatus, Fusarium oxysporum, and Verticillium dahliae with MIC values in the range of 1.56–6.25 μg ml⁻¹.

肠道真菌是肠道菌群的重要组成部分，能够产生专门的代谢产物，对维持肠道菌群的平衡和促进宿主有机体的健康有显着贡献。在本研究中，从肠道真菌镰刀菌中分离出两种新的糖苷，包括fusintespyrone A ( 1 )和cerevisterolside A ( 4 )，以及十种已知化合物。LE06。新化合物的结构通过质谱（MS）和核磁共振（NMR）等光谱方法的结合，以及化学反应以及NMR和ECD光谱的计算来阐明。化合物1-3对烟曲霉、^尖孢镰刀菌和大丽轮枝菌具有显着的生长抑制作用， MIC值在1.56-6.25 μg ml -1范围内。