Physical inactivity and obesity are growing concerns, negatively impacting the general population. Moderate physical activity is known to have a beneficial anti-inflammatory effect. N-glycosylation of immunoglobulin G (IgG) reflects changes in the inflammatory potential of IgG. In this study, GlycanAge index of biological age (GlycanAge), one of the first commercially used biomarkers of aging, was employed to assess effects of exercise intensity in three different groups of athletes: professional competing athletes, regularly moderate active individuals and newly involved recreational individuals, compared to the group of inactive individuals. GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02). Competing female athletes had significantly higher GlycanAge comparing to active females exercising moderately (β = 20.206, p.adj = 2.71E-02), while the latter had significantly lower GlycanAge when compared with the inactive counterparts (β = -9.762, p.adj = 4.68E-02). Regular, life-long moderate exercise has an anti-inflammatory effect in both female and male population, demonstrated by lower GlycanAge index, and it has great potential to mitigate growing issues related to obesity and a sedentary lifestyle, which are relentlessly increasing world-wide.

缺乏身体活动和肥胖日益引起人们的关注，对普通人群产生了负面影响。众所周知，适度的体力活动具有有益的抗炎作用。免疫球蛋白 G (IgG) 的 N-糖基化反映了 IgG 炎症潜力的变化。在这项研究中，生物年龄的 GlycanAge 指数 (GlycanAge) 是最早商业化使用的衰老生物标志物之一，用于评估运动强度对三组不同运动员的影响：职业竞技运动员、定期适度运动的个人和新参与休闲活动的运动员个体，与不活跃的个体群体相比。与不活动组相比，活动组的 GlycanAge 显着较低（β = -7.437，p.adj = 7.85E-03），与活动组相比，职业运动员名义上显着且有所增加（β = 7.546，p = 3.20） E-02）。与进行适度运动的活跃女性运动员相比，参加比赛的女运动员的聚糖年龄显着较高（β = 20.206，p.adj = 2.71E-02），而后者的聚糖年龄则显着低于不活跃的运动员（β = -9.762，p.adj） = 4.68E-02)。定期、终生的适度运动对女性和男性人群都具有抗炎作用，这一点可以通过较低的聚糖年龄指数来证明，而且它具有巨大的潜力，可以缓解与肥胖和久坐生活方式相关的日益严重的问题，这些问题在世界范围内不断增加。