Litter size (total number born) trait has a great impact on the economic success of pork production. The total number born consists of the number of piglets born alive and dead. To clarify the genetic background of litter size, genome-wide association studies were undertaken in the present study. Samples of DNA were collected and genotyped using the Porcine 50K BeadChip from 723 Dongliao Black sows. Using three different models (BLINK, FarmCPU, and MLM), a total of 155 significant SNPs were discovered, six of which had been reported in previous pig reproduction association studies. We suggest that rs81318434, located in the GLI3 gene, might be the promising candidate affecting litter size trait. Our findings may provide insights for uncovering the genetic mechanisms for the litter size of pigs.

中文翻译：

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东辽黑猪产仔数和死仔数的全基因组关联研究

产仔数（总出生数）性状对猪肉生产的经济成功有很大影响。出生总数包括活产仔猪数和死仔猪数。为了阐明产仔数的遗传背景，本研究进行了全基因组关联研究。使用 Porcine 50K BeadChip 从 723 头东辽黑母猪收集 DNA 样本并进行基因分型。使用三种不同的模型（BLINK、FarmCPU 和 MLM），总共发现了 155 个显着的 SNP，其中 6 个已在之前的猪繁殖关联研究中报告过。我们认为，位于GLI3基因中的 rs81318434可能是影响产仔数性状的有希望的候选者。我们的研究结果可能为揭示猪产仔数的遗传机制提供见解。