Background. After tooth extraction, alveolar bone resorption is inevitable. This clinical phenomenon challenges dental surgeons aiming to restore esthetic and function. Alveolar ridge preservation can be applied to minimize dimensional changes with a new socket grafting material, an autogenous dentin graft, produced by mechanically and chemically processing natural teeth. This study assessed the safety and efficacy of using autogenous dentin biomaterial in alveolar ridge preservation. Materials and Methods. Patients with nonrestorable maxillary anterior teeth bounded by natural sound teeth were included in this study. After a detailed clinical and tomographic examination, eligible participants were randomly allocated into two groups. The control group had spontaneous healing of extraction sockets. The study group had their extraction sockets filled with autogenous dentin biomaterial after processing their extracted retained roots with the KometaBio device. Standardized cone beam computed tomography (CBCT) scans were repeated four months later. A full-thickness mucoperiosteal flap reflection was achieved under local anesthesia to get core biopsies for histomorphometric analysis, and dental implants were placed at the same session. Results. A total of 32 eligible patients were included in this study ( in each group). Both groups had significantly higher facial soft tissue thickness after four months than baseline (). However, the study group showed statistically significant lesser dimensional changes than the control group according to the standardized CBCT scans. Furthermore, core biopsies confirmed an excellent remodeling of the autogenous dentin biomaterial in the study group. In comparison, only new thin bone trabeculae-filled sockets were in the control group. Conclusion. Autogenous dentin graft can be safely and successfully used for alveolar ridge preservation. Optimal graft remodeling histologically, better ridge dimensional stability, and uneventful wound healing support its clinical application. This trial is registered with TCTR20220615002.

中文翻译：

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自体牙本质生物材料对牙槽嵴保存的功效：随机对照临床试验

背景。拔牙后，牙槽骨吸收是不可避免的。这种临床现象对旨在恢复美观和功能的牙科医生提出了挑战。牙槽嵴保存可用于最大程度地减少尺寸变化，使用一种新的牙槽移植材料，即自体牙本质移植物，通过机械和化学加工天然牙齿制成。本研究评估了使用自体牙本质生物材料保存牙槽嵴的安全性和有效性。材料和方法。本研究包括具有天然健全牙齿边界的不可修复上颌前牙的患者。经过详细的临床和断层扫描检查后，符合条件的参与者被随机分为两组。对照组拔牙窝自然愈合。研究小组使用 KometaBio 设备处理拔出的保留牙根后，用自体牙本质生物材料填充拔牙槽。四个月后，重复进行标准化锥形束计算机断层扫描（CBCT）扫描。在局部麻醉下进行全层粘骨膜瓣反射，以获得用于组织形态计量分析的核心活检，并在同一疗程中植入牙种植体。结果。本研究共纳入 32 名符合条件的患者（每组）。四个月后，两组的面部软组织厚度均显着高于基线（）。然而，根据标准化 CBCT 扫描，研究组的尺寸变化明显小于对照组。此外，核心活检证实了研究组中自体牙本质生物材料的良好重塑。相比之下，对照组中只有新的薄骨小梁填充的窝。结论。自体牙本质移植物可以安全、成功地用于牙槽嵴保存。最佳的组织学重塑、更好的牙槽嵴尺寸稳定性和顺利的伤口愈合支持其临床应用。该试验已在 TCTR20220615002 上注册。