The intimately connected physiology of the cardiovascular and pulmonary systems gives rise to numerous shared risk factors and disease pathways, contributing significantly to the high incidence of co-occurring heart and lung diseases.1 For example, individuals diagnosed with asthma are at 15%–53% higher risk of cardiovascular disease (CVD),2 while those diagnosed with chronic obstructive pulmonary disease (COPD) have 2–5 times higher CVD risk.3 The association between respiratory impairment and CVD is not restricted to individuals with diagnosed respiratory conditions. Indeed, several studies have shown that impaired lung function, regardless of diagnosis, is associated with heightened CVD risk.4 5 However, the implications of such associations for clinical practice and policymaking have remained underexplored. Multivariable risk prediction is the cornerstone of primary prevention of CVD.6 For instance, statin therapy and lifestyle modifications are recommended for individuals without history of CVD when their predicted 10-year risk of CVD exceeds 5%–10%.7 Risk prediction is based on traditional risk factors including age, smoking history, blood pressure and serum lipids. The relevance of lung function measures in CVD risk estimation depends on the degree by which lung function remains a predictor of CVD, over and beyond the risk predicted by a scoring tool. This important question was tackled by the study by Zhou et al , published in this issue of Thorax .8 Compared with previous studies,5 9 this study provides unique insights into …

中文翻译：

---

肺功能作为心血管疾病风险的独立预测因子：对实践和政策的影响

心血管和肺系统的生理机能密切相关，产生了许多共同的危险因素和疾病途径，极大地导致了同时发生的心肺疾病的高发病率。1 例如，被诊断患有哮喘的个体为 15%–53心血管疾病 (CVD) 的风险较高2，而被诊断患有慢性阻塞性肺病 (COPD) 的人的 CVD 风险要高 2-5 倍。3 呼吸障碍与 CVD 之间的关联并不限于诊断患有呼吸系统疾病的个体。事实上，多项研究表明，无论诊断如何，肺功能受损都与 CVD 风险升高相关。4 5 然而，这种关联对临床实践和政策制定的影响仍未得到充分探索。多变量风险预测是​​ CVD 一级预防的基石。6 例如，当无 CVD 病史的个体预测 10 年 CVD 风险超过 5%–10% 时，建议进行他汀类药物治疗和改变生活方式。7 风险预测基于传统的危险因素包括年龄、吸烟史、血压和血脂。肺功能测量在 CVD 风险评估中的相关性取决于肺功能作为 CVD 预测因子的程度，超过评分工具预测的风险。 Zhou 等人发表在本期《Thorax》上的研究解决了这个重要问题。8 与之前的研究相比，5 9 这项研究提供了独特的见解……