Abstract

The stability of synthetic and natural zeolites in model biological media simulating the environment of the stomach (pH 1.8), blood plasma (pH 6.9), and intestines (pH 8) is studied. The effect of long-term exposure (up to 7 days) to biological media on the crystal structure of Beta, Rho, Y, and clinoptilolite zeolites is studied. The degree of degradation of the crystal structure of zeolites is controlled by X-ray phase analysis. Based on the results obtained, conclusions are drawn on the prospects for the use of synthetic and natural zeolites as drug carriers.

中文翻译：

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沸石在模型生物环境中的稳定性研究

摘要

研究了模拟胃（pH 1.8）、血浆（pH 6.9）和肠（pH 8）环境的模型生物介质中合成和天然沸石的稳定性。研究了长期暴露于生物介质（最多 7 天）对 Beta、Rho、Y 和斜发沸石晶体结构的影响。沸石晶体结构的降解程度由X射线物相分析控制。根据所获得的结果，得出了合成和天然沸石作为药物载体的应用前景的结论。