Their health industry is facing challenges due to a rise in mortality rates brought on by various multi-drug-resistant bacterial strains. As a result, new and improvedantibacterial drugs are urgently needed. Similarly, when some unwanted foreign pathogensenter the cellular premises to disturb its homeostasis, inflammation develops as an immune reaction. However, these immune responses also become a double-edged sword when the inflammatory reaction lasts for a long time, and pain is also linked to inflammatory responses. Inflammation and pain are both signs of tissue injury. Pain is,by definition, an unpleasant experience that ultimately interferes with their normalwell-being. Hence, bacterial infection, inflammation, and pain need medical assistance to maintain homeostasis. Conventional medicines possess so many repercussive effects, which then demand a replacement with a less toxic and more efficient modern drug. In their review article, for the first time, they present recent advancements in biomedical applications such as the antimicrobial, anti-inflammatory, and analgesic properties of noble metal nanoparticles. Noble metals have limited availability in the earth's crust. Hence, their physicochemical characterizations and applications are greatly limited. Still, there are some interesting research findings that offer a significant ray of hope for the health sector all over the world.

中文翻译：

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贵金属纳米粒子抗菌、抗炎、镇痛性能综合评述

由于各种多重耐药菌株导致死亡率上升，他们的健康产业正面临挑战。因此，迫切需要新的和改进的抗菌药物。同样，当一些不需要的外来病原体进入细胞场所扰乱其稳态时，炎症就会作为免疫反应而发展。然而，当炎症反应持续较长时间时，这些免疫反应也成为一把双刃剑，而疼痛也与炎症反应有关。炎症和疼痛都是组织损伤的迹象。根据定义，疼痛是一种不愉快的经历，最终会干扰他们的正常健康。因此，细菌感染、炎症和疼痛需要医疗帮助来维持体内平衡。传统药物具有如此多的副作用，因此需要用毒性更小、更有效的现代药物来替代。在他们的评论文章中，他们首次介绍了贵金属纳米粒子的抗菌、抗炎和镇痛特性等生物医学应用的最新进展。贵金属在地壳中的可用性有限。因此，它们的物理化学特性和应用受到很大限制。尽管如此，还是有一些有趣的研究结果为世界各地的卫生部门带来了一线希望。