Introduction

Silicone breast implants (SBI) result in immune dysregulation and are associated with autoimmune diseases. Recently, we reported dysregulated levels of IgG autoantibodies directed against G protein-coupled receptors (GPCRs) of the autonomic nervous system which were linked to the autoimmune dysautonomia in silicone breast implant illness (SBII).

Aims

We aimed to explore the possible association between allergy with dysregulated IgE autoantibodies directed against GPCRs of the autonomic nervous system in women with SBI.

Methods

Circulating levels of IgE autoantibodies against GPCRs of the autonomic nervous system (adrenergic, muscarinic, endothelin and angiotensin receptors) have been evaluated in women with SBIs who complained of allergic symptoms, and compared to subjects with SBI without allergic manifestations and to age-matched healthy women without SBI.

Results

We report a significant dysregulation in three circulating autoantibodies: IgE-beta1 adrenergic receptor (B1AR), IgE-alpha 1 adrenergic receptor (A1AR) and IgE-muscarinic acetylcholine receptor type 1 (M1R) autoantibodies in women with SBI who complained of allergic symptoms.

Conclusions

Allergic reactions associated with SBI are not uncommon. Imbalance of circulating levels of IgE autoantibodies against GPCRs of the autonomic nervous system might play a role not only in allergic reactions, but also in other enigmatic aspects of SBII such as autoimmune dysautonomia.

中文翻译：

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硅胶隆胸女性的过敏表现

介绍

硅胶乳房植入物(SBI) 会导致免疫失调，并与自身免疫性疾病相关。最近，我们报道了针对自主神经系统 G 蛋白偶联受体 (GPCR) 的IgG自身抗体水平失调，这与硅胶乳房植入物疾病 (SBII) 中的自身免疫性自主神经功能异常有关。

目标

我们的目的是探讨 SBI 女性过敏与针对自主神经系统 GPCR 的 IgE 自身抗体失调之间可能存在的关联。

方法

在患有过敏症状的 SBI 女性中评估了针对自主神经系统 GPCR（肾上腺素能、毒蕈碱、内皮素和血管紧张素受体）的 IgE 自身抗体的循环水平，并与没有过敏表现的 SBI 受试者和年龄匹配的健康受试者进行了比较没有 SBI 的女性。

结果

我们报告称，患有过敏症状的 SBI 女性中，三种循环自身抗体存在显着失调：IgE-β1 肾上腺素能受体 (B1AR)、IgE-α1 肾上腺素能受体 (A1AR) 和 IgE-毒蕈碱乙酰胆碱受体 1 型 (M1R) 自身抗体。

结论

与 SBI 相关的过敏反应并不罕见。针对自主神经系统 GPCR 的 IgE 自身抗体循环水平的不平衡可能不仅在过敏反应中发挥作用，而且在 SBII 的其他神秘方面（例如自身免疫性自主神经功能障碍）中也发挥作用。