Coca tea is a popular drink in some countries of South America where it is presented as a safe energy preparation, based on a limited total content of cocaine of about 3 to 5 mg. Tea bags can be bought with no legal considerations in these countries both by locals and tourists but its consumption can have consequences when consumed overseas. Driving under the influence of cocaine is banned in most places in the world and can be documented by oral fluid testing. A study was implemented with coca tea bags (Coca & Muna) purchased in Peru, after a French attorney at law contacted the laboratory to assess the involvement of coca tea in the positive oral fluid results of a driver. Ten healthy volunteers consumed 250 mL of coca tea containing 4.5 mg of cocaine. No volunteer reported any change in behavioral effects after consumption of the coca tea. Oral fluid was collected with a swab (FloqSwab™, Copan) over 8 hours to follow the elimination of cocaine and its major metabolites (benzoylecgonine and ecgonine methylester). This is the procedure used by the French police. All samples were analyzed by UHPLC–MS-MS after Quantisal™ buffer desorption. As the device does not allow measurement of the amount of collected fluid, the results are qualitative. This is in accordance with the French law that requires a yes or no response about the presence of cocaine, with a minimum required performance level of 10 ng/ml of cocaine or benzoylecgonine. Parent cocaine was identified for 30 to 120 min. Benzoylecgonine and ecgonine methylester were identified between 1 and 8 hours, with a large inter-individual variation. Although it is generally accepted that a 4 to 5 mg cocaine dose has no significant pharmacological effect, the consumption of coca tea can lead to the suspension of a person’s driving license due to a positive oral fluid test.

中文翻译：

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饮用古柯茶后使用 FloqSwab™ 收集的口腔液中可卡因相关生物碱的检测窗口

古柯茶在南美洲的一些国家是一种流行的饮料，在这些国家，它被认为是一种安全的能量制剂，可卡因的总含量有限，约为 3 至 5 毫克。在这些国家，当地人和游客都可以在没有法律考虑的情况下购买茶包，但在海外消费时，茶包的消费可能会产生后果。世界上大多数地方都禁止在可卡因的影响下驾驶，并且可以通过口腔液测试来记录。在一位法国律师联系实验室评估古柯茶与一名司机口腔液阳性结果的关系后，对在秘鲁购买的古柯茶袋 (Coca & Muna) 进行了一项研究。10 名健康志愿者饮用了 250 毫升古柯茶，其中含有 4.5 毫克可卡因。没有志愿者报告饮用古柯茶后行为影响有任何变化。在 8 小时内用拭子（FloqSwab™，Copan）收集口腔液，以消除可卡因及其主要代谢物（苯甲酰爱康宁和爱康宁甲酯）。这是法国警方使用的程序。所有样品均在 Quantisal™ 缓冲液解吸后通过 UHPLC-MS-MS 进行分析。由于该设备不允许测量收集的液体量，因此结果是定性的。这符合法国法律，要求对可卡因的存在做出“是”或“否”的回答，可卡因或苯甲酰爱康宁的最低性能水平为 10 纳克/毫升。母体可卡因的鉴定时间为 30 至 120 分钟。苯甲酰爱康宁和芽子宁甲酯在1至8小时内被鉴定，个体间差异较大。尽管人们普遍认为4至5毫克的可卡因剂量没有显着的药理作用，但饮用古柯茶可能会因口腔液体测试呈阳性而导致吊销驾驶执照。