Treatment options for acquired tracheal stenosis (ATS) are limited due to a series of pathophysiological changes including inflammation and cell proliferation. Micro ribonucleic acid-21-5p (miR-21-5p) may promote the excessive proliferation of fibroblasts. However, various types of fibrosis can be prevented with pirfenidone (PFD). Currently, the effect of PFD on miR-21-5p and its biological function has not been clarified. In this study, PFD was evaluated as a potential treatment for ATS by inducing fibroblast proliferation in lipopolysaccharide (LPS)-induced fibroblasts by targeting miR-21-5p.

中文翻译：

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吡非尼酮下调 miR-21-5p 抑制成纤维细胞增殖治疗获得性气管狭窄

由于炎症和细胞增殖等一系列病理生理变化，获得性气管狭窄（ATS）的治疗选择受到限制。微小核糖核酸-21-5p（miR-21-5p）可能促进成纤维细胞过度增殖。然而，吡非尼酮（PFD）可以预防各种类型的纤维化。目前，PFD对miR-21-5p的影响及其生物学功能尚未明确。在这项研究中，PFD 通过靶向 miR-21-5p 来诱导脂多糖 (LPS) 诱导的成纤维细胞增殖，从而被评估为 ATS 的潜在治疗方法。