Objective

To determine burden and identify correlates of erectile dysfunction (ED) among men with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS).

Research design and methods

The 2017 DPPOS visit included administration of the International Index of Erectile Function. Of 648 male participants, 88 % (n = 568) completed the survey. Associations between sociodemographic, behavioral, clinical, and glycemic measures at time of ED assessment, and ED were examined using multivariable logistic regression models in men with PreD and T2D separately.

Results

Overall, 218 (38 %) men met ED criteria. Prevalence was similar in men with PreD (41 %) and T2D (37 %) (p = 0.4). In all men, age (p < 0.001) increased odds of ED. Among men with PreD, those assigned to intensive lifestyle intervention (ILS), but not metformin, had decreased odds of ED compared with the placebo group (OR = 0.35, 95 % CI = 0.13, 0.94). Non-Hispanic White race was associated with increased odds of ED compared with other races (OR = 4.3; 95 % CI = 1.92, 9.65). Among men with T2D, ED risk did not differ by DPP treatment assignment; however, individuals with metabolic syndrome defined by National Cholesterol Education Program criteria, had increased odds of ED (OR = 1.85, 95 % CI = 1.14, 3.01), as did individuals with depression (OR = 2.05; 95 % CI = 1.10, 3.79).

Conclusions

ED is prevalent in men with PreD and T2D. Our finding of reduced odds of ED in men randomized to ILS and with PreD suggests a potential opportunity for risk mitigation in the prediabetes interval. In men who have progressed to T2D, metabolic factors appear to be associated with ED.

中文翻译：

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糖尿病预防计划结果研究中男性勃起功能障碍的患病率和预测因素

客观的

旨在确定参加糖尿病预防计划 (DPP) 结果研究 (DPPOS) 的糖尿病前期 (PreD) 和 2 型糖尿病 (T2D)男性的负担并确定勃起功能障碍 (ED) 的相关性。

研究设计和方法

2017 年 DPPOS 访问包括管理国际勃起功能指数。在 648 名男性参与者中，88% (n = 568) 完成了调查。使用多变量逻辑回归模型分别对患有 PreD 和 T2D 的男性检查 ED 评估时的社会人口统计学、行为、临床和血糖测量以及 ED 之间的关联。

结果

总体而言，218 名 (38%) 男性符合 ED 标准。PreD (41%) 和 T2D (37%) 男性的患病率相似 (p = 0.4)。在所有男性中，年龄 (p < 0.001) 会增加 ED 的几率。在患有 PreD 的男性中，与安慰剂组相比，接受强化生活方式干预 (ILS)（但不接受二甲双胍）的男性 ED 几率降低（OR = 0.35，95% CI = 0.13，0.94）。与其他种族相比，非西班牙裔白人种族与 ED 几率增加相关（OR = 4.3；95 % CI = 1.92, 9.65）。在患有 T2D 的男性中，ED 风险并没有因 DPP 治疗分配的不同而存在差异；然而，根据国家胆固醇教育计划标准定义的代谢综合征患者，患 ED 的几率增加（OR = 1.85，95 % CI = 1.14，3.01），抑郁症患者也是如此（OR = 2.05；95 % CI = 1.10，3.79） ）。

结论

ED 在患有 PreD 和 T2D 的男性中很常见。我们发现随机接受 ILS 和 PreD 的男性患 ED 的几率降低，这表明在糖尿病前期间隔期间存在降低风险的潜在机会。在已发展为 T2D 的男性中，代谢因素似乎与 ED 相关。