The increasing bacterial resistance highlights the necessity of developing superior antibacterial materials. Metal-doped carbon dots (CDs), a crucial branch of carbon-based nanozymes, exhibit efficient antibacterial properties using the reactive oxygen species (ROS) effect. In this study, iron-doped carbon dots (Fe-CDs) are synthesized with high peroxidase-like (POD-like) activity using natural hemin as a precursor for the first time. The formation of Fe-CDs remarkably improves the water solubility of hemin showing excellent biocompatibility. Additionally, iron is doped from hemin to the CDs surface, reducing the risk of trial-and-error associated with adding an external iron source. The Fe-CDs-hydrogel system is constructed via the incorporation of Fe-CDs into a dual-crosslinked injectable hydrogel, taking advantage of the synergistic effects. The system enhances the mechanical properties of hydrogel and serves as an excellent carrier for Fe-CDs. It exhibits effective antibacterial activity at low hydrogen peroxide (H₂O₂) concentrations (10⁻⁴ m) via the activation of Fenton-like reaction-triggered POD-like catalytic activity and the electrostatic interactions. The system further demonstrates excellent healing efficacy in a bacteria-infected wound model by reducing inflammation levels and accelerating the regeneration of tissues. This study provides a novel approach for applying nanozymes in antibacterial therapy and wound healing.

中文翻译：

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掺有铁掺杂碳点的可注射水凝胶具有类似过氧化物酶的活性，可用于抗菌治疗和伤口愈合

细菌耐药性的增加凸显了开发优质抗菌材料的必要性。金属掺杂碳点（CD）是碳基纳米酶的一个重要分支，利用活性氧（ROS）效应表现出高效的抗菌特性。在这项研究中，首次使用天然氯化血红素作为前体合成了具有高过氧化物酶样（POD 样）活性的铁掺杂碳点（Fe-CD）。 Fe-CDs的形成显着提高了氯高铁血红素的水溶性，表现出优异的生物相容性。此外，铁从氯化血红素掺杂到 CD 表面，降低了与添加外部铁源相关的反复试验的风险。 Fe-CDs-水凝胶系统是通过将 Fe-CDs 纳入双交联可注射水凝胶中构建的，利用了协同效应。该系统增强了水凝胶的机械性能，并可作为 Fe-CD 的优异载体。它通过激活类芬顿反应触发的类POD催化活性和静电相互作用，在低过氧化氢（H ₂ O ₂）浓度（10 ^-4  m ）下表现出有效的抗菌活性。该系统通过降低炎症水平和加速组织再生，在细菌感染的伤口模型中进一步展示了优异的愈合功效。这项研究为纳米酶在抗菌治疗和伤口愈合中的应用提供了一种新方法。