Abstract

Aurora kinases are essential players in mammalian cell division. These kinases are involved in the regulation of spindle dynamics, microtubule–kinetochore interactions, and chromosome condensation and orientation during mitosis. At least three members of the Aurora family – Aurora kinases A, B, and C – have been identified in mammals. Aurora B is essential for maintaining genomic stability and normal cell division. Mutations and dysregulation of this kinase are implicated in tumor initiation and progression. In this review, we discuss the functions of Aurora B, the relationship between increased Aurora B activity and carcinogenesis, and the prospects for the use of Aurora B kinase inhibitors in antitumor therapy.

中文翻译：

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Aurora B 激酶在正常细胞和癌细胞中的作用

摘要

极光激酶是哺乳动物细胞分裂的重要参与者。这些激酶参与有丝分裂过程中纺锤体动力学、微管-着丝粒相互作用以及染色体凝聚和定向的调节。已在哺乳动物中鉴定出 Aurora 家族的至少三个成员 - 极光激酶 A、B 和 C。Aurora B 对于维持基因组稳定性和正常细胞分裂至关重要。该激酶的突变和失调与肿瘤的发生和进展有关。在这篇综述中，我们讨论了Aurora B的功能、Aurora B活性增加与致癌之间的关系，以及Aurora B激酶抑制剂在抗肿瘤治疗中的应用前景。