This study examines the complex relationship between pancreatic cancer (PC) and type 2 diabetes (T2D) by focusing on the role of microRNAs (miRNAs). miRNAs are small non-coding RNAs that regulate gene expression and have been implicated in many diseases, including T2D and cancer. To begin, we conducted a literature review to identify miRNAs associated with the PC-T2D link. However, we found limited research on this specific association, with most studies focusing on the antitumor effects of metformin. Furthermore, we performed a bioinformatics analysis to identify new potential miRNAs that might be relevant in the context of PC-T2D. First, we identified miRNAs and gene expression alterations common to both diseases using publicly available datasets. Subsequently, we performed an integrative analysis between the identified miRNAs and genes alterations. As a result, we identified nine miRNAs that could potentially play an important role in the interplay between PC and T2D. These miRNAs have the potential to influence nearby cells and distant tissues, affecting critical processes like extracellular matrix remodeling and cell adhesion, ultimately contributing to the development of T2D or PC. Taken together, these analyses underscore the importance of further exploring the role of miRNAs in the complex interplay of PC and T2D.

本研究通过关注 microRNA (miRNA) 的作用，探讨了胰腺癌 (PC) 和 2 型糖尿病 (T2D) 之间的复杂关系。miRNA 是调节基因表达的小非编码 RNA，与许多疾病有关，包括 T2D 和癌症。首先，我们进行了文献综述，以确定与 PC-T2D 链接相关的 miRNA。然而，我们发现对这种特定关联的研究有限，大多数研究都集中在二甲双胍的抗肿瘤作用上。此外，我们进行了生物信息学分析，以确定可能与 PC-T2D 相关的新的潜在 miRNA。首先，我们使用公开数据集确定了这两种疾病共有的 miRNA 和基因表达改变。随后，我们对已识别的 miRNA 和基因改变进行了综合分析。结果，我们鉴定了 9 个可能在 PC 和 T2D 之间的相互作用中发挥重要作用的 miRNA。这些 miRNA 有可能影响附近的细胞和远处的组织，影响细胞外基质重塑和细胞粘附等关键过程，最终促进 T2D 或 PC 的发展。总而言之，这些分析强调了进一步探索 miRNA 在 PC 和 T2D 复杂相互作用中的作用的重要性。