S100 calcium-binding protein B (S100B) and glucose control are reflective of maternal-fetal risks. We investigated the value of serum S100B combined with fasting blood glucose (FBG)/hemoglobin A1c (HbA1c) in evaluating the pregnancy outcomes of patients with severe preeclampsia (SPE). The clinical characteristics of SPE patients/controls were collected. FBG/HbA1c and serum S100B levels were measured, with their correlations analyzed. SPE patients were subdivided into adverse/non-adverse outcome groups based on follow-up results. The value of different indexes in predicting pregnancy outcomes was analyzed. SPE patients showed higher systolic blood pressure, diastolic blood pressure, urine protein, and body mass index and lower platelets, gestational age at delivery, and infant birth weight than healthy controls. FBG and HbA1c were positively correlated with serum S100B. SPE patients with adverse outcomes exhibited increased serum S100B and FBG/HbA1c levels. The area under the curve of serum S100B + FBG/HbA1c in evaluating adverse pregnancy outcomes of SPE patients was 0.8412 (77.05% sensitivity/84.21% specificity), higher than either alone. Serum S100B and FBG/HbA1c were independent risk factors for adverse outcomes of SPE patients. Overall, serum S100B positively-correlates with FBG/HbA1c in SPE patients. Serum S100B and FBG/HbA1c are independent risk factors, and their combination has high value on predicting adverse pregnancy outcomes of SPE patients.

S100 钙结合蛋白 B (S100B) 和血糖控制反映了母婴风险。我们探讨了血清S100B联合空腹血糖（FBG）/糖化血红蛋白（HbA1c）在评估重度子痫前期（SPE）患者妊娠结局中的价值。收集 SPE 患者/对照的临床特征。测量 FBG/HbA1c 和血清 S100B 水平，并分析其相关性。根据随访结果，SPE 患者被分为不良/非不良结果组。分析不同指标对妊娠结局的预测价值。与健康对照组相比，SPE 患者的收缩压、舒张压、尿蛋白和体重指数较高，血小板、分娩胎龄和婴儿出生体重较低。FBG、HbA1c与血清S100B呈正相关。具有不良结果的 SPE 患者表现出血清 S100B 和 FBG/HbA1c 水平升高。血清S100B+FBG/HbA1c评估SPE患者不良妊娠结局的曲线下面积为0.8412（敏感性77.05%/特异性84.21%），高于单独使用任一方法。血清S100B和FBG/HbA1c是SPE患者不良结局的独立危险因素。总体而言，SPE 患者的血清 S100B 与 FBG/HbA1c 呈正相关。血清S100B和FBG/HbA1c是独立的危险因素，两者联合对预测SPE患者不良妊娠结局具有较高价值。