Borderline personality disorder (BPD) is characterized by maladaptive levels of neuroticism, agreeableness, and conscientiousness. The Unified Protocol (UP), a treatment for neuroticism, has previously demonstrated promising effects when applied to BPD; however, not all individuals with BPD respond, suggesting the UP may be incomplete for some BPD presentations. This secondary analysis explored the extent to which adapted versions of UP represent an efficacious treatment approach for BPD symptoms. Data from a subset of twelve participants with clinically-significant BPD features were included. We explored within-group changes in BPD symptoms and differences in within-person changes in BPD scores based on patients’ personality profiles. The UP resulted in improvements in BPD symptoms that were moderate in magnitude, Hedges’s g = 0.48, 95% CI [0.35, 0.62]. Individuals with personality profiles characterized by high neuroticism and low conscientiousness exhibited early gains in the UP but did not sustain them, whereas those with at least moderate levels of conscientiousness generally continued to improve across 12 weeks. Possible explanations and limitations were discussed.

边缘性人格障碍（BPD）的特点是神经质、宜人性和责任心的适应不良水平。统一方案（UP）是一种治疗神经质的方法，此前在应用于 BPD 时已显示出良好的效果。然而，并非所有 BPD 患者都会做出回应，这表明 UP 对于某些 BPD 演示可能不完整。这项二次分析探讨了 UP 的改编版本在多大程度上代表了 BPD 症状的有效治疗方法。包括 12 名具有临床显着 BPD 特征的参与者的数据。我们根据患者的性格概况，探讨了 BPD 症状的组内变化以及 BPD 评分的人内变化差异。UP 导致 BPD 症状得到中等程度的改善，Hedges g = 0.48，95% CI [0.35，0.62]。具有高神经质和低责任心的性格特征的个体在 UP 中表现出早期的进步，但没有维持这种进步，而那些至少具有中等责任心水平的个体通常在 12 周内持续改善。讨论了可能的解释和限制。