Hypoxia-inducible factor 1 (HIF1) is a transcription factor that is stabilized under hypoxia conditions via post-translational modifications. HIF1 regulates tumor malignancy and metastasis by gene transcriptions, such as Warburg effect and angiogenesis-related genes, in cancer cells. However, the HIF1 downstream genes show varied expressional patterns in different cancer types. Herein, we performed the hierarchical clustering based on the HIF1 downstream gene expression patterns using 1406 cancer cell lines crossing 30 types of cancer to understand the relationship between HIF1 downstream genes and the metastatic potential of cancer cell lines. Two types of cancers, including bone and breast cancers, were classified based on HIF1 downstream genes with significantly altered metastatic potentials. Furthermore, different HIF1 downstream gene subsets were extracted to discriminate each subtype for these cancer types. HIF1 downstream subtyping classification will help to understand the novel insight into tumor malignancy and metastasis in each cancer type.

中文翻译：

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泛癌细胞系中根据缺氧诱导因子 1 下游基因分类的转移潜能

缺氧诱导因子 1 (HIF1) 是一种转录因子，可通过翻译后修饰在缺氧条件下保持稳定。 HIF1通过癌细胞中的Warburg效应和血管生成相关基因等基因转录来调节肿瘤的恶性和转移。然而，HIF1 下游基因在不同的癌症类型中表现出不同的表达模式。在此，我们使用跨越30种癌症的1406个癌细胞系，基于HIF1下游基因表达模式进行层次聚类，以了解HIF1下游基因与癌细胞系转移潜力之间的关系。根据转移潜力显着改变的 HIF1 下游基因对两种类型的癌症（包括骨癌和乳腺癌）进行分类。此外，还提取了不同的 HIF1 下游基因子集来区分这些癌症类型的每种亚型。 HIF1 下游亚型分类将有助于了解每种癌症类型的肿瘤恶性肿瘤和转移的新见解。