Objective. To investigate the clinical and pathological effects of serum C3 level, mesangial C3 deposition intensity and blood lipid on IgA nephropathy. Methods. According to the deposition intensity of immunofluorescence (IF) complement C3 in mesangial region, a total of 151 patients were divided into: (1) negative group (65 cases), (2) weak positive group (51 cases), and (3) strong positive group (35 cases). According to the level of serum C3, the patients were divided into two groups: (1) 33 patients with decreased serum C3 (<85 mg/dL); (2) 118 patients with normal serum C3. The clinicopathological data of the patients were analyzed retrospectively according to the groups. Results. (1) With the increase of C3 deposition in mesangial region, the mean value of serum C3 level decreased, and the difference was statistically significant (). (2) Compared with the normal serum C3 group, the blood urea nitrogen (BUN), serum creatinine (Scr), and albumin (Alb) in the serum C3 decreased group were higher, and the differences were statistically significant (), while the fasting blood glucose (FBG), low-density lipoprotein (LDL), triglyceride and 24-hr urinary protein (24hUTP) were lower, which difference was statistically significant (). (3) Compared with negative group and weak positive group, BUN, uric acid (UA), and Scr were higher in the strong positive group with C3 deposition, while eGFR was lower, with statistical significance (). However, C3 deposition in the mesangial region was related to T and enhanced mesangial C3 deposition was associated with more severe tubular atrophy and/or interstitial fibrosis, with statistically significant differences (). Conclusion. Patients with strong mesangial C3 deposition and elevated lipid levels had more severe tubule atrophy and/or interstitial fibrosis, as well as more severe pathological lesions, suggesting that activation of the complement system is involved in the pathogenesis of IgA nephropathy and increases the metabolic burden of the kidney.

中文翻译：

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IgA肾病患者血清C3水平和系膜C3强度的临床和病理影响

客观的。探讨血清C3水平、系膜C3沉积强度及血脂对IgA肾病的临床及病理影响。方法。根据系膜区免疫荧光（IF）补体C3沉积强度，将151例患者分为：（1）阴性组（65例），（2）弱阳性组（51例），（3）强阳性组(35例)。根据血清C3水平，将患者分为两组：（1）血清C3降低（<85 mg/dL）33例；(2)118例血清C3正常的患者。按分组对患者的临床病理资料进行回顾性分析。结果。(1)随着系膜区C3沉积的增加，血清C3水平平均值降低，差异有统计学意义(）。(2)与血清C3正常组相比，血清C3降低组的血尿素氮(BUN)、血清肌酐(Scr)、白蛋白(Alb)较高，差异有统计学意义(），而空腹血糖（FBG）、低密度脂蛋白（LDL）、甘油三酯和24小时尿蛋白（24hUTP）较低，差异有统计学意义（）。(3)与阴性组和弱阳性组相比，有C3沉积的强阳性组BUN、尿酸(UA)、Scr较高，eGFR较低，差异有统计学意义(）。然而，系膜区域的 C3 沉积与 T 相关，系膜 C3 沉积增强与更严重的肾小管萎缩和/或间质纤维化相关，具有统计学显着差异（）。 结论。系膜C3沉积较强、血脂水平升高的患者，肾小管萎缩和/或间质纤维化更严重，病理病变也更严重，提示补体系统的激活参与了IgA肾病的发病机制，并增加了肾小球肾病的代谢负担。肾脏。