Background. Using a fluid-filled wire with a pressure sensor outside the patient compared to a conventional pressure wire may avoid the systematic error introduced by the hydrostatic pressure within the coronary circulation. Aims. To assess the safety and effectiveness of the novel fluid-filled wire, Wirecath (Cavis Technologies, Uppsala, Sweden), as well as its ability to avoid the hydrostatic pressure error. Methods and Results. The Wirecath pressure wire was used in 45 eligible patients who underwent invasive coronary angiography and had a clinical indication for invasive coronary pressure measurement at Sahlgrenska University Hospital, Gothenburg, Sweden. In 29 patients, a simultaneous measurement was performed with a conventional coronary pressure wire (PressureWire X, Abbott Medical, Plymouth, MN, USA), and in 19 patients, the vertical height difference between the tip of the guide catheter and the wire measure point was measured in a 90-degree lateral angiographic projection. No adverse events caused by the pressure wires were reported. The mean Pd/Pa and mean FFR using the fluid-filled wire and the sensor-tipped wire differed significantly; however, after correcting for the hydrostatic effect, the sensor-tipped wire pressure correlated well with the fluid-filled wire pressure (R = 0.74 vs. R = 0.89 at rest and R = 0.89 vs. R = 0.98 at hyperemia). Conclusion. Hydrostatic errors in physiologic measurements can be avoided by using the fluid-filled Wirecath wire, which was safe to use in the present study. This trial is registered with NCT04776577 and NCT04802681.

中文翻译：

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使用充满液体的导线避免生理冠状动脉测量中的静水压力误差的安全性和可行性

背景。与传统的压力导丝相比，在患者体外使用带有压力传感器的流体填充导丝可以避免冠状循环内的静水压力引入的系统误差。目标。为了评估新型流体填充线 Wirecath（Cavis Technologies，瑞典乌普萨拉）的安全性和有效性，以及其避免静水压力误差的能力。方法和结果。Wirecath 压力丝用于 45 名符合条件的患者，这些患者在瑞典哥德堡萨尔格伦斯卡大学医院接受了侵入性冠状动脉造影，并具有侵入性冠状动脉压力测量的临床指征。对 29 名患者使用传统冠状动脉压力导丝（PressureWire X，Abbott Medical，普利茅斯，明尼苏达州，美国）进行同步测量，并在 19 名患者中测量导引导管尖端与导丝测量点之间的垂直高度差通过 90 度横向血管造影投影进行测量。没有报告由压力线引起的不良事件。使用流体填充导线和传感器尖端导线的平均 Pd/Pa 和平均 FFR 存在显着差异；然而，在校正流体静力效应后，传感器尖端的线压力与充满液体的线压力密切相关（ 静止时R  = 0.74 与R = 0.89，充血时R  = 0.89 与R  = 0.98）。结论。通过使用充满液体的 Wirecath 线可以避免生理测量中的流体静力误差，该线在本研究中使用是安全的。该试验注册号为 NCT04776577 和 NCT04802681。