Intestinal epithelium is a dynamic cellular layer that lines the small-bowel and makes a relatively impenetrable barrier to macromolecules. Intestinal epithelial cell polarity is crucial in coordinating signalling pathways within cells and mainly regulated by three conserved polarity protein complexes, the Crumbs (Crb) complex, partitioning defective (PAR) complex, and Scribble (Scrib) complex. Polarity proteins regulate the proper establishment of the intercellular junctional complexes including tight junctions (TJs), adherence junctions (AJs), and desmosomes which hold epithelial cells together and play a major role in maintaining intestinal barrier integrity. Impaired intestinal epithelial cell polarity and barrier integrity result in irreversible immune responses, the host- microbial imbalance and intestinal inflammatory disorders. Disassembling the epithelial tight junction and augmented paracellular permeability is a conspicuous hallmark of celiac disease (CD) pathogenesis. There are several dietary components that can improve intestinal integrity and function. The aim of this review article is to summarize current information about the association of polarity proteins and AJC damages with pathogenesis of CD.

肠上皮是一个动态的细胞层，排列在小肠内，并对大分子形成相对难以穿透的屏障。肠上皮细胞极性对于协调细胞内的信号通路至关重要，主要由三种保守的极性蛋白复合物调节，即 Crumbs (Crb) 复合物、分区缺陷 (PAR) 复合物和 Scribble (Scrib) 复合物。极性蛋白调节细胞间连接复合物的正确建立，包括紧密连接 (TJ)、粘附连接 (AJ) 和桥粒，这些连接将上皮细胞固定在一起，并在维持肠道屏障完整性方面发挥重要作用。肠上皮细胞极性和屏障完整性受损会导致不可逆的免疫反应、宿主微生物失衡和肠道炎症性疾病。上皮紧密连接的分解和细胞旁通透性的增强是乳糜泻（CD）发病机制的显着标志。有几种饮食成分可以改善肠道完整性和功能。本文的目的是总结有关极性蛋白和 AJC 损伤与 CD 发病机制之间关系的最新信息。