The histone lysine demethylase 3 A (KDM3A) is vital for the regulation of cancer physiology and pathophysiology. The purpose of this study was to investigate the effect of KDM3A expression with triple-negative breast cancer (TNBC) invasion and metastasis. In our results, knockout of KDM3A in TNBC MDA-MB-231 cells promoted apoptosis and inhibited the proliferation, invasion and metastasis of MDA-MB-231 cells. In addition, we found that in vivo experiments indicated that the growth, invasion and metastasis of metastatic neoplasms were significantly inhibited by knockout of KDM3A in a TNBC metastasis model. These findings suggest that KDM3A may be a potential therapeutic target for the treatment and prevention of TNBC, providing a critical theoretical basis for the effective prevention or treatment of breast cancer disease.

组蛋白赖氨酸去甲基酶 3 A (KDM3A) 对于癌症生理学和病理生理学的调节至关重要。本研究的目的是探讨KDM3A表达与三阴性乳腺癌（TNBC）侵袭和转移的影响。在我们的结果中，TNBC MDA-MB-231细胞中KDM3A的敲除促进细胞凋亡并抑制MDA-MB-231细胞的增殖、侵袭和转移。此外，我们发现体内实验表明，在TNBC转移模型中敲除KDM3A可显着抑制转移性肿瘤的生长、侵袭和转移。这些发现表明KDM3A可能是治疗和预防TNBC的潜在治疗靶点，为有效预防或治疗乳腺癌疾病提供了重要的理论基础。