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Latest advances in hepatocellular carcinoma management and prevention through advanced technologies
Egyptian Liver Journal Pub Date : 2024-01-02 , DOI: 10.1186/s43066-023-00306-3
Tamer A. Addissouky , Ibrahim El Tantawy El Sayed , Majeed M. A. Ali , Yuliang Wang , Ayman El Baz , Ahmed A. Khalil , Naglaa Elarabany

Hepatocellular carcinoma (HCC) is a common type of liver cancer, with a high mortality rate. Hepatocellular carcinoma is a type of liver cancer that can be effectively managed through early detection and accurate diagnosis, followed by a personalized treatment plan that may include surgical resection, liver transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending on the stage and severity of the cancer. This paper discusses recent advances in the early detection, management, and prevention of HCC. The use of newer imaging techniques, such as Magnetic resonance imaging (MRI) and contrast-enhanced ultrasound, along with image segmentation technology and deep learning models, have greatly enhanced the accuracy of HCC detection and diagnosis. Minimally-invasive techniques, such as thermal ablation and radiofrequency ablation, have allowed for more precise and targeted destruction of tumors, while Nanoparticles, immunotherapy and targeted therapy have shown promise in the management of advanced stage HCC. The use of Artificial intelligence (AI) and machine learning has revolutionized HCC research, aiding in the identification of high-risk patients and predicting outcomes. Lifestyle modifications, such as weight management, alcohol avoidance, and hepatitis B vaccinations, can play a critical role in preventing HCC development. Recent advances in early detection, management, and prevention of HCC have shown promise in improving patient outcomes. The use of newer imaging techniques, minimally-invasive techniques, immunotherapy, targeted therapy, and AI and machine learning have greatly enhanced HCC research and management, while lifestyle modifications can play a critical role in prevention. However, further research is required to fully understand the potential benefits of nanoparticles, traditional Chinese medicine and herbal medicines in HCC treatment. • Early detection and diagnosis: The advent of newer imaging techniques, such as MRI, contrast-enhanced ultrasound, and image segmentation technology, has allowed for earlier and more accurate detection of HCC, with higher sensitivity and specificity than previous techniques. Advances in radiomics and deep learning models have greatly enhanced the accuracy of HCC diagnosis. • AI and machine learning: The use of AI and machine learning has revolutionized HCC research, with greater accuracy and an ability to analyze large volumes of data. AI-based predictive models have been shown to be helpful in identifying high-risk patients and predicting outcomes. • Management: While surgical resection and liver transplantation remain effective treatments for early-stage HCC, advances in minimally-invasive techniques, such as thermal ablation and radiofrequency ablation, have allowed for more precise and targeted destruction of tumors. Additionally, nanoparticles, immunotherapy and targeted therapy have shown significant promise in the management of advanced stage HCC. • Prevention: Lifestyle modifications, such as weight management and alcohol avoidance, along with hepatitis B vaccinations, can play a critical role in preventing HCC development. • Traditional Chinese medicine and herbal medicines in HCC treatment require further investigation.

中文翻译:

通过先进技术控制和预防肝细胞癌的最新进展

肝细胞癌(HCC)是一种常见的肝癌,死亡率很高。肝细胞癌是一种肝癌,可以通过早期发现和准确诊断来有效管理,然后根据阶段和情况制定个性化治疗计划,包括手术切除、肝移植、微创技术、免疫治疗或靶向治疗。癌症的严重程度。本文讨论了 HCC 早期检测、治疗和预防方面的最新进展。磁共振成像 (MRI) 和超声造影等新型成像技术的使用,以及图像分割技术和深度学习模型,大大提高了 HCC 检测和诊断的准确性。热消融和射频消融等微创技术可以更精确、更有针对性地破坏肿瘤,而纳米颗粒、免疫疗法和靶向治疗在晚期 HCC 的治疗中显示出希望。人工智能 (AI) 和机器学习的使用彻底改变了 HCC 研究,有助于识别高风险患者并预测结果。改变生活方式,例如体重管理、避免饮酒和接种乙型肝炎疫苗,可以在预防肝癌发展方面发挥关键作用。HCC 早期检测、管理和预防方面的最新进展显示出改善患者预后的希望。更新的成像技术、微创技术、免疫疗法、靶向治疗以及人工智能和机器学习的使用极大地增强了肝癌的研究和管理,而生活方式的改变可以在预防中发挥关键作用。然而,还需要进一步的研究来充分了解纳米颗粒、中药和草药在 HCC 治疗中的潜在益处。• 早期检测和诊断:MRI、超声造影和图像分割技术等新型成像技术的出现,可以更早、更准确地检测出 HCC,并且比以前的技术具有更高的灵敏度和特异性。放射组学和深度学习模型的进步极大地提高了 HCC 诊断的准确性。• 人工智能和机器学习:人工智能和机器学习的使用彻底改变了 HCC 研究,具有更高的准确性和分析大量数据的能力。基于人工智能的预测模型已被证明有助于识别高风险患者和预测结果。• 治疗:虽然手术切除和肝移植仍然是早期HCC 的有效治疗方法,但热消融和射频消融等微创技术的进步使得能够更精确、更有针对性地破坏肿瘤。此外,纳米粒子、免疫疗法和靶向疗法在晚期 HCC 的治疗中显示出巨大的前景。• 预防:生活方式的改变,例如体重管理和避免饮酒,以及乙型肝炎疫苗接种,可以在预防 HCC 发展方面发挥关键作用。• 中药和草药在HCC 治疗中的作用需要进一步研究。
更新日期:2024-01-03
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