Signal transducer and activator of transcription 3 (STAT3), as a key node in numerous carcinogenic signaling pathways, is activated in various tumor tissues and plays important roles in tumor formation, metastasis, and drug resistance. STAT3 is considered a potential subtarget for tumor therapy. Noncoding RNA (ncRNA) is a special type of RNA transcript. Transforming from “junk” transcripts into key molecules involved in cell apoptosis, growth, and functional regulation, ncRNA has been proven to be closely related to various epithelial–mesenchymal transition and drug resistance processes in tumor cells over the past few decades. Research on the relationship between transcription factor STAT3 and ncRNAs has attracted increased attention. To date, existing reviews have mainly focused on the regulation by ncRNAs on the transcription factor STAT3; there has been no review of the regulation by STAT3 on ncRNAs. However, understanding the regulation of ncRNAs by STAT3 and its mechanism is important to comprehensively understand the mutual regulatory relationship between STAT3 and ncRNAs. Therefore, in this review, we summarize the regulation by transcription factor STAT3 on long noncoding RNA, microRNA, and circular RNA and its possible mechanisms. In addition, we provide an update on research progress on the regulation of STAT3 by ncRNAs. This will provide a new perspective to comprehensively understand the regulatory relationship between transcription factor STAT3 and ncRNAs, as well as targeting STAT3 or ncRNAs to treat diseases such as tumors.

中文翻译：

---

转录因子STAT3与非编码RNA的调控关系

信号转导和转录激活因子3（STAT3）作为众多致癌信号通路的关键节​​点，在多种肿瘤组织中被激活，在肿瘤的形成、转移和耐药中发挥着重要作用。STAT3被认为是肿瘤治疗的潜在子靶标。非编码 RNA (ncRNA) 是一种特殊类型的 RNA 转录物。ncRNA从“垃圾”转录物转变为参与细胞凋亡、生长和功能调节的关键分子，在过去的几十年里已被证明与肿瘤细胞的各种上皮-间质转化和耐药过程密切相关。转录因子STAT3与ncRNA之间关系的研究越来越受到关注。迄今为止，现有的综述主要集中在ncRNA对转录因子STAT3的调控上；目前尚未审查 STAT3 对 ncRNA 的调节作用。然而，了解STAT3对ncRNA的调控及其机制对于全面了解STAT3与ncRNA之间的相互调控关系具有重要意义。因此，本文综述了转录因子STAT3对长链非编码RNA、微小RNA和环状RNA的调控及其可能的机制。此外，我们还提供了 ncRNA 调控 STAT3 的最新研究进展。这将为全面理解转录因子STAT3与ncRNA之间的调控关系，以及靶向STAT3或ncRNA治疗肿瘤等疾病提供新的视角。