Insulin-like growth factor 2 (IGF2) mRNA-binding proteins 2 (IGF2BP2/IMP2), an RNA-binding protein encoded by the IGF2BP2 gene, exerts its influence across diverse pathological pathways. While accumulating evidence underscores the potential significance of IGF2BP2 in the tumorigenesis of specific cancers, a comprehensive pan-cancer investigation into its role remains absent. Consequently, we conducted an exhaustive exploration employing a multitude of databases to elucidate the plausible oncogenic implications of IGF2BP2. This encompassed a comprehensive scrutiny of its expression profiles, prognostic implications, association with cancer-associated fibroblast infiltration, biological functionality in distinct tumor contexts, and plausible correlations with drug sensitivities. Our findings showed that IGF2BP2 was highly expressed in some types of cancers, but presented at low levels in several cancer types. Furthermore, the role of IGF2BP2 in predicting prognosis exhibited a dichotomous interplay across varied cancer types. Remarkably, observations unveiled the cancer-associated fibroblast infiltration within specific tumors, notably encompassing breast invasive carcinoma of the luminal A subtype, kidney renal clear cell carcinoma, ovarian serous cystadenocarcinoma, pheochromocytoma and paraganglioma, and prostate adenocarcinoma, and thymoma. Intriguingly, gene enrichment analyses spotlighted the co-expression of IGF2BP2 with genes implicated in pivotal biological processes, including DNA replication and recombinational repair. Our investigation intricately unveils the potential of IGF2BP2 as a versatile prognostic biomarker across diverse tumor categories. This study bridges existing knowledge gaps and augments the understanding of IGF2BP2’s intricate involvement in tumorigenesis, underscoring its significance as a prospective avenue for therapeutic intervention.

中文翻译：

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泛癌症分析确定 IGF2BP2 是多种肿瘤类型的潜在预后生物标志物

胰岛素样生长因子 2 (IGF2) mRNA 结合蛋白 2 (IGF2BP2/IMP2) 是一种由 IGF2BP2 基因编码的 RNA 结合蛋白，在多种病理途径中发挥影响。虽然越来越多的证据强调了 IGF2BP2 在特定癌症的肿瘤发生中的潜在重要性，但对其作用的全面的泛癌研究仍然缺乏。因此，我们利用大量数据库进行了详尽的探索，以阐明 IGF2BP2 可能的致癌影响。这包括对其表达谱、预后影响、与癌症相关成纤维细胞浸润的关联、不同肿瘤背景下的生物功能以及与药物敏感性的合理相关性进行全面审查。我们的研究结果表明，IGF2BP2 在某些类型的癌症中高表达，但在几种癌症类型中低水平表达。此外，IGF2BP2 在预测预后中的作用在不同癌症类型中表现出二分相互作用。值得注意的是，观察结果揭示了特定肿瘤内与癌症相关的成纤维细胞浸润，特别是管腔 A 亚型的乳腺浸润性癌、肾肾透明细胞癌、卵巢浆液性囊腺癌、嗜铬细胞瘤和副神经节瘤、前列腺腺癌和胸腺瘤。有趣的是，基因富集分析强调了 IGF2BP2 与参与关键生物过程（包括 DNA 复制和重组修复）的基因的共表达。我们的研究复杂地揭示了 IGF2BP2 作为跨不同肿瘤类别的多功能预后生物标志物的潜力。这项研究弥补了现有的知识空白，增强了对 IGF2BP2 在肿瘤发生中复杂参与的理解，强调了其作为治疗干预的前瞻性途径的重要性。