The purpose of this study was to understand and analyze the risk factors of peripherally inserted central catheter (PICC)-related venous thrombosis in adult patients with cancer. This observational cohort study included adult patients with cancer who underwent color Doppler ultrasound at the Xiangya Hospital of Central South University, Hunan Provincial Maternal and Child Healthcare Hospital, and Xiangya Changde Hospital, Hunan Province, from January 1, 2017 to December 31, 2021. Univariate and multivariate logistic regression analyses were performed to determine the risk factors of PICC-related venous thrombosis. After risk adjustment, multivariate logistic regression analysis revealed statistically significant associations between PICC-related venous thrombosis and age > 65 years old (OR: 1.791, CI: 1.343–2.389), male sex (OR: 1.398, CI: 1.057–1.849), white blood cell count > 9.5 × 109 /L (OR: 1.422, CI: 1.041–1.942), APTT < 25 s (OR: 2.006, CI: 1.431–2.811), gastrointestinal tumor (OR: 2.191, CI: 1.406–3.414), infection (OR:7.619, CI: 5.783–10.037), the use of cisplatin (OR: 2.374, CI: 1.714–3.214), vincristine (OR: 2.329, CI: 1.447–3.749), the use of polyurethane (OR: 2.449, CI: 1.863–3.219) and open-ended catheters (OR:1.660, CI: 1.131–2.439), keeping time of the catheter (days) (OR: 1.003, CI: 1.001–1.005) were associated with PICC-related venous thrombosis. We identified that the presence of age > 65 years old, male sex, white blood cell count > 9.5 × 109 /L, APTT < 25 s, gastrointestinal tumor, infection, the use of cisplatin and vincristine, the use of polyurethane, open-ended catheters and keeping time of the catheter (days), were associated with PICC-related venous thrombosis.

中文翻译：

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成年癌症患者经外周静脉置入中心导管相关静脉血栓形成的危险因素

本研究的目的是了解和分析成年癌症患者外周静脉置入中心静脉导管（PICC）相关静脉血栓形成的危险因素。这项观察性队列研究纳入了2017年1月1日至2021年12月31日在中南大学湘雅医院、湖南省妇幼保健院和湖南省湘雅常德医院接受彩色多普勒超声检查的成年癌症患者。通过单因素和多因素logistic回归分析确定PICC相关静脉血栓形成的危险因素。风险调整后，多因素logistic回归分析显示PICC相关静脉血栓形成与年龄> 65岁（OR：1.791，CI：1.343–2.389）、男性（OR：1.398，CI：1.057–1.849）、白细胞计数 > 9.5 × 109 /L（OR：1.422，CI：1.041–1.942），APTT < 25 s（OR：2.006，CI：1.431–2.811），胃肠道肿瘤（OR：2.191，CI：1.406–3.414） ）、感染（OR：7.619，CI：5.783–10.037）、使用顺铂（OR：2.374，CI：1.714–3.214）、长春新碱（OR：2.329，CI：1.447–3.749）、使用聚氨酯（OR：2.329，CI：1.447–3.749） ：2.449，CI：1.863–3.219）和开放式导管（OR：1.660，CI：1.131–2.439）、导管保留时间（天）（OR：1.003，CI：1.001–1.005）与 PICC 相关。相关静脉血栓形成。我们确定存在年龄>65岁、男性、白细胞计数>9.5×109/L、APTT<25s、胃肠道肿瘤、感染、使用顺铂和长春新碱、使用聚氨酯、开放式导管的终止和导管的保留时间（天）与PICC相关的静脉血栓形成相关。