We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit anti-tumor immunity without the need for ex vivo antigen loading.

中文翻译：

---

一种无需抗原负载的自体抗原不可知树突状细胞疗法

我们开发了一种从骨髓或血液中分离的造血干细胞和祖细胞生成树突状细胞祖细胞（DCP）的方法。当经过改造以表达 IL-12 和 FLT3L 时，这些 DCP 会重新编程肿瘤微环境并引发抗肿瘤免疫，而无需离体抗原负载。