Cooling crystallization is an important separation process and particuology technology that requires accurate nucleation control strategies. Herein, we introduced the polymeric hollow fiber membrane with proper thermal properties as the effective nucleation induction interface during cooling crystallization. The heterogeneous nucleation control mechanism was introduced based on classical nucleation theory and the thermal transfer process. Interfacial properties and the thermal conductivity of two kinds of polymeric membranes, polytetrafluoroethylene (PTFE) and polyethersulfone (PES), were measured and simulated with the developed model. These two membranes possessed different nucleation induction periods, nucleation rates and crystallization performances, which validated that the hollow fiber membrane module could effectively accelerate the nucleation process compared to conventional cooling crystallization owing to the shorter nucleation induction period and the reduced solution surface tension. Due to the higher hydrophobicity and the lower roughness of the membrane surface, the PTFE membrane possessed a more moderate performance in generating stable heterogeneous nucleation than the one of PES membrane. Thus, the adjustable membrane property enabled the hollow fiber membrane-assisted cooling crystallization to possess the accurate nucleation control and desired terminal particle products.

冷却结晶是一种重要的分离过程和颗粒学技术，需要精确的成核控制策略。在此，我们引入了具有适当热性能的聚合物中空纤维膜作为冷却结晶过程中有效的成核诱导界面。基于经典成核理论和热传递过程，引入了异相成核控制机制。使用开发的模型测量和模拟了聚四氟乙烯（PTFE）和聚醚砜（PES）两种聚合物膜的界面特性和导热率。这两种膜具有不同的成核诱导期、成核速率和结晶性能，验证了中空纤维膜组件由于成核诱导期更短和溶液表面张力降低，与传统冷却结晶相比可以有效加速成核过程。由于PTFE膜具有较高的疏水性和较低的膜表面粗糙度，因此PTFE膜在产生稳定的异质成核方面比PES膜具有更温和的性能。因此，可调节的膜特性使得中空纤维膜辅助冷却结晶具有精确的成核控制和所需的终端颗粒产物。