Burn injuries can be associated with prolonged healing, infection, a substantial inflammatory response, extensive scarring, and eventually death. In recent decades, both the mortality rates and long-term survival of severe burn victims have improved significantly, and burn care research has increasingly focused on a better quality of life post-trauma. However, delayed healing, infection, pain and extensive scar formation remain a major challenge in the treatment of burns. ADSCs, a distinct type of mesenchymal stem cells, have been shown to improve the healing process. The aim of this review is to evaluate the efficacy of ADSCs in the treatment of burn injuries. A systematic review of the literature was conducted using the electronic databases PubMed, Web of Science and Embase. The basic research question was formulated with the PICO framework, whereby the usage of ADSCs in the treatment of burns in vivo was determined as the fundamental inclusion criterion. Additionally, pertinent journals focusing on burns and their treatment were screened manually for eligible studies. The review was registered in PROSPERO and reported according to the PRISMA statement. Of the 599 publications screened, 21 were considered relevant to the key question and were included in the present review. The included studies were almost all conducted on rodents, with one exception, where pigs were investigated. 13 of the studies examined the treatment of full-thickness and eight of deep partial-thickness burn injuries. 57,1 percent of the relevant studies have demonstrated that ADSCs exhibit immunomodulatory effects during the inflammatory response. 16 studies have shown improved neovascularisation with the use of ADSCs. 14 studies report positive influences of ADSCs on granulation tissue formation, while 11 studies highlight their efficacy in promoting re-epithelialisation. 11 trials demonstrated an improvement in outcomes during the remodelling phase. In conclusion, it appears that adipose-derived stem cells demonstrate remarkable efficacy in the field of regenerative medicine. However, the usage of ADSCs in the treatment of burns is still at an early experimental stage, and further investigations are required in order to examine the potential usage of ADSCs in future clinical burn care.

中文翻译：

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脂肪干细胞在烧伤中的功效：系统评价

烧伤可能会导致愈合时间延长、感染、严重的炎症反应、广泛的疤痕，甚至最终死亡。近几十年来，严重烧伤患者的死亡率和长期生存率均得到显着改善，烧伤护理研究越来越关注创伤后更好的生活质量。然而，延迟愈合、感染、疼痛和大面积疤痕形成仍然是烧伤治疗的主要挑战。ADSC 是一种独特类型的间充质干细胞，已被证明可以改善愈合过程。本综述的目的是评估 ADSC 在治疗烧伤中的疗效。使用电子数据库 PubMed、Web of Science 和 Embase 对文献进行了系统回顾。基础研究问题是用 PICO 框架制定的，其中 ADSC 在体内烧伤治疗中的使用被确定为基本纳入标准。此外，还手动筛选了关注烧伤及其治疗的相关期刊，以寻找符合条件的研究。该审查已在 PROSPERO 中注册，并根据 PRISMA 声明进行报告。在筛选的 599 份出版物中，有 21 份被认为与关键问题相关并纳入本次审查。纳入的研究几乎都是在啮齿动物身上进行的，但有一项例外，即对猪进行了研究。其中 13 项研究考察了全层烧伤和 8 项深度部分烧伤的治疗。57.1% 的相关研究表明 ADSC 在炎症反应过程中表现出免疫调节作用。16 项研究表明，使用 ADSC 可改善新血管形成。14 项研究报告了 ADSC 对肉芽组织形成的积极影响，同时 11 项研究强调了它们在促进上皮再形成方面的功效。11 项试验证明重塑阶段的结果有所改善。总之，脂肪干细胞在再生医学领域表现出显着的功效。然而，ADSCs在烧伤治疗中的应用仍处于早期实验阶段，需要进一步研究以检验ADSCs在未来临床烧伤治疗中的潜在用途。